Design and feasibility of a novel personal protection device against airborne pathogens for everyday use

IF 2.2 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

Journal of virological methods Pub Date : 2025-06-16 DOI:10.1016/j.jviromet.2025.115203

Gary Leschinsky , W. Andrew Dexter , Barbara Leschinsky , Jeffery Trolinger

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引用次数: 0

Abstract

Airborne viruses, such as SARS-CoV-2, influenza, and potentially emerging avian influenza, are a major cause of disease spread. Airborne disease outbreaks have increased by 35 times in the past 20 years. These viruses are particularly a concern for immunocompromised individuals worldwide. ActivAir is a patented novel reusable personal protection device designed to provide a pathogen-free personal air supply. Ambient air is passed under UVC light inside a small, enclosed chamber before being released as a gentle breeze over the face of the user. Feasibility tests with a prototype disinfection chamber of the device showed a 99.99 % efficiency in a single-pass deactivation of aerosolized Phi X 174 bacteriophage, and over 96 % efficiency in deactivating aerosolized MS2 bacteriophage, both are known surrogates for SARS-COV-2, influenza, and other airborne viruses. High-efficiency UVC LEDs consume low enough energy to make this battery-powered device wearable and easy to use, lasting several hours on a single charge. This device holds a promise of providing efficient everyday protection for immunocompromised patients today, as well as a new line of defense for everyone in case of a future pandemic.

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一种日常使用的新型个人防护装置的设计和可行性

空气传播的病毒，如SARS-CoV-2、流感和可能出现的禽流感，是疾病传播的主要原因。在过去的20年里，空气传播疾病的爆发增加了35倍。这些病毒是全世界免疫功能低下个体特别关注的问题。ActivAir是一种获得专利的新型可重复使用的个人防护装置，旨在提供无病原体的个人空气供应。环境空气在紫外线照射下通过一个封闭的小房间，然后以微风的形式从使用者的脸上释放出来。使用该设备的原型消毒室进行可行性测试表明，单次灭活雾化的Phi X 174噬菌体的效率为99.99 %，灭活雾化的MS2噬菌体的效率超过96% %，两者都是已知的SARS-COV-2、流感和其他空气传播病毒的替代品。高效率的UVC led消耗足够低的能量，使这种电池供电的设备可穿戴且易于使用，一次充电可使用数小时。这种装置有望为今天的免疫功能低下患者提供有效的日常保护，以及在未来大流行的情况下为每个人提供新的防线。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of virological methods 医学-病毒学

CiteScore

5.80

自引率

0.00%

发文量

209

审稿时长

41 days

期刊介绍： The Journal of Virological Methods focuses on original, high quality research papers that describe novel and comprehensively tested methods which enhance human, animal, plant, bacterial or environmental virology and prions research and discovery. The methods may include, but not limited to, the study of: Viral components and morphology- Virus isolation, propagation and development of viral vectors- Viral pathogenesis, oncogenesis, vaccines and antivirals- Virus replication, host-pathogen interactions and responses- Virus transmission, prevention, control and treatment- Viral metagenomics and virome- Virus ecology, adaption and evolution- Applied virology such as nanotechnology- Viral diagnosis with novelty and comprehensive evaluation. We seek articles, systematic reviews, meta-analyses and laboratory protocols that include comprehensive technical details with statistical confirmations that provide validations against current best practice, international standards or quality assurance programs and which advance knowledge in virology leading to improved medical, veterinary or agricultural practices and management.