Fungal-derived chitosan-based hydrogels with antimicrobial properties for infectious wound healing

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2025-06-17 DOI:10.1016/j.carbpol.2025.123917

Ding Zhou , XinQing Li , Ying Zhu , Yaxin Hu , Siying Zhang , Zan Tong , Yingshan Zhou , Yun Chen

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引用次数: 0

Abstract

Persistent bacterial infections hinder wound healing by disrupting tissue repair and perpetuating inflammatory states. However, conventional therapies adopting antibiotics and passive dressings could only suppress pathogens temporarily and ignore antibiotic resistance or actively promote regenerative microenvironments. Herein, based on fungal-derived chitosan, guanidinium-functionalized chitosan (GCS) and aldehyde-modified chitosan (ACS) were synthesized, then chitosan hydrogels (SCgel) with self-healing capacity were prepared via the Schiff base reaction between GCS and ACS. Through a simple local injection through a dual-barrel syringe, a protective SCgel hydrogel barrier can be rapidly established on the wound. This hydrogel not only quickly eliminates bacteria in infected wounds but also reduces the level of wound inflammation, thereby promoting wound healing. In infected full-thickness rat wounds, SCgel achieved a 94.5 ± 1.1 % wound closure rate within 14 days, significantly superior to commercial silver-coated Aquacel™ Ag⁺. By integrating potent antimicrobial activity with inflammation control, this design reduces the reliance on systemic antibiotics and addresses the unmet need for microenvironment-responsive wound dressings.

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真菌衍生的壳聚糖基水凝胶具有抗菌特性，用于感染性伤口愈合

持续的细菌感染通过破坏组织修复和延续炎症状态来阻碍伤口愈合。然而，采用抗生素和被动敷料的常规治疗只能暂时抑制病原体，忽略抗生素耐药性或积极促进再生微环境。在真菌源壳聚糖的基础上，合成了胍功能化壳聚糖（GCS）和醛修饰壳聚糖（ACS），并通过GCS与ACS之间的希夫碱反应制备了具有自愈能力的壳聚糖水凝胶（SCgel）。通过双筒注射器进行简单的局部注射，可以在伤口上迅速建立保护性的凝胶水凝胶屏障。这种水凝胶不仅可以快速清除感染伤口中的细菌，还可以减少伤口的炎症程度，从而促进伤口愈合。在感染的全层大鼠伤口中，SCgel在14天内实现了94.5±1.1%的伤口愈合率，显著优于商业镀银的Aquacel™Ag+。通过将有效的抗菌活性与炎症控制相结合，这种设计减少了对全身抗生素的依赖，并解决了微环境反应性伤口敷料的未满足需求。

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.