Altered resting-state amygdala-cerebellar functional connectivity is associated with intolerance of uncertainty in patients with obsessive-compulsive disorder: A longitudinal study

IF 4.8 2区医学 Q1 PSYCHIATRY

Journal of Anxiety Disorders Pub Date : 2025-06-13 DOI:10.1016/j.janxdis.2025.103048

Qihui Guo , Rongrong Zhu , Huixia Zhou , Dongmei Wang , Xiangyang Zhang

{"title":"Altered resting-state amygdala-cerebellar functional connectivity is associated with intolerance of uncertainty in patients with obsessive-compulsive disorder: A longitudinal study","authors":"Qihui Guo , Rongrong Zhu , Huixia Zhou , Dongmei Wang , Xiangyang Zhang","doi":"10.1016/j.janxdis.2025.103048","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Intolerance of uncertainty (IU) plays an important role in the pathology of obsessive-compulsive disorder (OCD). The amygdala and anterior insula (AI) appear to be important neural correlates of IU. However, the relationship between altered resting-state functional connectivity (rsFC) and IU in OCD patients has not been reported.</div></div><div><h3>Methods</h3><div>This study recruited 39 patients with OCD and 45 healthy controls (HC). IU was measured using the Intolerance of Uncertainty Scale (IUS). The seed-to-voxel method was used to construct rsFC maps. Between-group differences in rsFC and their correlations with IU were analyzed. Following an eight-week psychological intervention, OCD patients underwent a second assessment. The association between rsFC changes and IU changes was investigated.</div></div><div><h3>Results</h3><div>OCD patients exhibited significantly higher IUS scores. Significant alterations in rsFC were observed between the left amygdala and the left cerebellum posterior lobe (CPL), as well as between the left AI and the left cuneus in OCD patients. In the OCD group, only the left amygdala - left CPL rsFC significantly correlated with IUS scores. No significant correlations were found between rsFC and IUS scores in the HC group. Longitudinal analysis revealed that changes in the left amygdala - left CPL rsFC were significantly associated with changes in IUS scores.</div></div><div><h3>Conclusions</h3><div>This study establishes amygdala-cerebellar rsFC as a specific neural signature of IU in patients with OCD, patterns absent in healthy controls. Moreover, the amygdala-cerebellar rsFC displayed longitudinal coupling with IU changes. These findings provide novel insights into the neural mechanisms of OCD pathology.</div></div>","PeriodicalId":48390,"journal":{"name":"Journal of Anxiety Disorders","volume":"114 ","pages":"Article 103048"},"PeriodicalIF":4.8000,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Anxiety Disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0887618525000842","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

Intolerance of uncertainty (IU) plays an important role in the pathology of obsessive-compulsive disorder (OCD). The amygdala and anterior insula (AI) appear to be important neural correlates of IU. However, the relationship between altered resting-state functional connectivity (rsFC) and IU in OCD patients has not been reported.

Methods

This study recruited 39 patients with OCD and 45 healthy controls (HC). IU was measured using the Intolerance of Uncertainty Scale (IUS). The seed-to-voxel method was used to construct rsFC maps. Between-group differences in rsFC and their correlations with IU were analyzed. Following an eight-week psychological intervention, OCD patients underwent a second assessment. The association between rsFC changes and IU changes was investigated.

Results

OCD patients exhibited significantly higher IUS scores. Significant alterations in rsFC were observed between the left amygdala and the left cerebellum posterior lobe (CPL), as well as between the left AI and the left cuneus in OCD patients. In the OCD group, only the left amygdala - left CPL rsFC significantly correlated with IUS scores. No significant correlations were found between rsFC and IUS scores in the HC group. Longitudinal analysis revealed that changes in the left amygdala - left CPL rsFC were significantly associated with changes in IUS scores.

Conclusions

This study establishes amygdala-cerebellar rsFC as a specific neural signature of IU in patients with OCD, patterns absent in healthy controls. Moreover, the amygdala-cerebellar rsFC displayed longitudinal coupling with IU changes. These findings provide novel insights into the neural mechanisms of OCD pathology.

查看原文本刊更多论文

静息状态杏仁核-小脑功能连接的改变与强迫症患者对不确定性的不耐受有关：一项纵向研究

目的不确定性不耐受（IU）在强迫症（OCD）病理中起重要作用。杏仁核和前岛（AI）似乎是IU的重要神经关联。然而，OCD患者静息状态功能连接改变（rsFC）与IU之间的关系尚未报道。方法招募强迫症患者39例，健康对照45例。IU采用不确定度不耐受度量表（IUS）测量。采用种子到体素的方法构建rsFC地图。分析rsFC的组间差异及其与IU的相关性。经过8周的心理干预后，强迫症患者接受了第二次评估。研究了rsFC变化与IU变化之间的关系。结果socd患者IUS评分明显增高。在强迫症患者中，左杏仁核和左小脑后叶（CPL）、左AI和左楔叶之间的rsFC发生了显著变化。在强迫症组中，只有左杏仁核-左CPL rsFC与IUS评分显著相关。HC组rsFC与IUS评分无显著相关性。纵向分析显示，左杏仁核-左CPL rsFC的变化与IUS评分的变化显著相关。结论本研究确立了杏仁核-小脑rsFC是强迫症患者IU的特异性神经特征，而这种特征在健康对照组中不存在。此外，杏仁核-小脑rsFC表现出与IU变化的纵向耦合。这些发现为强迫症病理的神经机制提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Anxiety Disorders Multiple-

CiteScore

16.60

自引率

2.90%

发文量

期刊介绍： The Journal of Anxiety Disorders is an interdisciplinary journal that publishes research papers on all aspects of anxiety disorders for individuals of all age groups, including children, adolescents, adults, and the elderly. Manuscripts that focus on disorders previously classified as anxiety disorders such as obsessive-compulsive disorder and posttraumatic stress disorder, as well as the new category of illness anxiety disorder, are also within the scope of the journal. The research areas of focus include traditional, behavioral, cognitive, and biological assessment; diagnosis and classification; psychosocial and psychopharmacological treatment; genetics; epidemiology; and prevention. The journal welcomes theoretical and review articles that significantly contribute to current knowledge in the field. It is abstracted and indexed in various databases such as Elsevier, BIOBASE, PubMed/Medline, PsycINFO, BIOSIS Citation Index, BRS Data, Current Contents - Social & Behavioral Sciences, Pascal Francis, Scopus, and Google Scholar.