Silicon Disulfide-Mediated Peptide Bond Formation: Implications of Environmental Factors on Prebiotic Synthesis

Abstract

The dominant view in abiogenesis research suggests that prebiotic reactions predominantly take place in aqueous or moist environments. Consequently, compounds unstable in water are often overlooked in studies of prebiotic chemistry. Here, we investigate peptide formation mediated by silicon disulfide (SiS₂), a compound detected in circumstellar shells, offering new insights into potential prebiotic pathways. To explore diverse conditions of early Earth, we experimentally simulated sulfur-rich volcanic environments, atmospheric variations, and light exposure. Our results reveal significant variations in peptide yields under different environmental conditions. This study not only enhances our understanding of peptide formation in anhydrous settings but also calls for a reassessment of the environmental factors influencing early prebiotic reactions.