A Novel, Targeted, Injectable Magnetic Composite for Self-Regulating Mild Hyperthermia Treatment of Bone Tumors with Improved Safety

IF 18.5 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Functional Materials Pub Date : 2025-06-18 DOI:10.1002/adfm.202418411

Zexu Ma, Zilin Zhang, Xiaoting Zhou, Jiaqi Dou, Yigong Zhang, Hai Wang, Bianyun Cai, Chuqi Zhang, Yujin Ma, Guangda Li

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Abstract

Magnetic hyperthermia (MH) mediated by biomaterials is a novel and promising method for treating deep-seated bone tumors; however, it is crucial to control the temperature to ensure efficacy and safety. In this study, a novel injectable magnetic composite cement (BBCM@HA) with self-regulating hyperthermic effects by loading hyaluronic acid (HA)-modified lanthanum strontium calcium manganese oxide on a matrix composed of calcium phosphate, calcium sulfate, and bioactive glass is developed. The cement has good injectability, can self-harden, resists washout, and is radiopaque. Cell experiments reveal that BBCM@HA can increase the proliferation, migration, mineralization, and alkaline phosphatase expression in MC3T3 cells. Notably, the cement with a Curie temperature of ≈50 °C can achieve stable, self-regulating mild MH in vivo under a biosafe alternating magnetic field (AMF), thus showing enhanced safety. Upon AMF application, the material kills MG63 cells in vitro and significantly suppresses subcutaneous tumor growth in mice. In addition, BBCM@HA repairs the bone defects formed by VX2 tumors in rabbits and inhibits bone tumor recurrence. Thus, BBCM@HA can treat bone tumors via self-regulated mild hyperthermia.

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一种新型、靶向、可注射的磁复合材料，用于自我调节的轻度热疗治疗骨肿瘤，提高了安全性

生物材料介导的磁热疗（MH）是一种治疗深部骨肿瘤的新方法。然而，控制温度是保证疗效和安全性的关键。在这项研究中，通过在磷酸钙、硫酸钙和生物活性玻璃组成的基质上加载透明质酸（HA）修饰的镧锶钙锰氧化物，开发了一种具有自调节热效应的新型可注射磁性复合水泥（BBCM@HA）。该水泥具有良好的可注射性、自硬化性、抗冲刷性、不透光性。细胞实验显示BBCM@HA可增加MC3T3细胞的增殖、迁移、矿化和碱性磷酸酶的表达。值得注意的是，居里温度≈50℃的水泥在生物安全交变磁场（AMF）下可以在体内实现稳定的、自我调节的轻度MH，从而增强了安全性。应用AMF后，该材料在体外杀死MG63细胞，并显著抑制小鼠皮下肿瘤生长。此外，BBCM@HA修复兔VX2肿瘤形成的骨缺损，抑制骨肿瘤复发。因此，BBCM@HA可以通过自我调节的轻度高温治疗骨肿瘤。

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来源期刊

Advanced Functional Materials 工程技术-材料科学：综合

CiteScore

29.50

自引率

4.20%

发文量

2086

审稿时长

2.1 months

期刊介绍： Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.