A Contemporary View of Mechanosensory Transduction in Auditory Hair Cells.

IF 3.2 3区生物学 Q2 BIOPHYSICS

Biophysical journal Pub Date : 2025-06-16 DOI:10.1016/j.bpj.2025.06.015

Matthew Mun,Jeffrey R Holt

引用次数: 0

Abstract

The ability to transduce the mechanical stimuli that initiate vertebrate hearing and balance is enabled by the stereociliary tips of inner ear hair cells, where a complex protein machine serves as a nexus for mechanosensory transduction (MT). The culmination of over two decades of work has illuminated many essential components of this protein complex, including the identification of TMC1 and TMC2, TMIE and CIB2 as obligatory subunits of hair cell MT channels. In this review, we highlight the work and history that has informed contemporary understanding of mechanosensory transduction, recent advances and challenges in characterizing MT proteins both individually and in context of the greater complex, and future directions necessary to fully understand the nature of hair cell MT and its molecular mechanisms.

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听觉毛细胞机械感觉传导的当代观点。

传导机械刺激的能力启动脊椎动物的听力和平衡是由内耳毛细胞的立体纤毛尖端实现的，其中一个复杂的蛋白质机器作为机械感觉传导（MT）的纽带。经过20多年的研究，研究人员已经阐明了该蛋白复合物的许多基本成分，包括鉴定TMC1和TMC2、TMIE和CIB2是毛细胞MT通道的必需亚基。在这篇综述中，我们强调了对机械感觉转导的当代理解的工作和历史，在个体和更大的复杂背景下表征MT蛋白的最新进展和挑战，以及充分了解毛细胞MT的本质及其分子机制所必需的未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biophysical journal 生物-生物物理

CiteScore

6.10

自引率

5.90%

发文量

3090

审稿时长

2 months

期刊介绍： BJ publishes original articles, letters, and perspectives on important problems in modern biophysics. The papers should be written so as to be of interest to a broad community of biophysicists. BJ welcomes experimental studies that employ quantitative physical approaches for the study of biological systems, including or spanning scales from molecule to whole organism. Experimental studies of a purely descriptive or phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ. Theoretical studies should offer new insights into the understanding ofexperimental results or suggest new experimentally testable hypotheses. Articles reporting significant methodological or technological advances, which have potential to open new areas of biophysical investigation, are also suitable for publication in BJ. Papers describing improvements in accuracy or speed of existing methods or extra detail within methods described previously are not suitable for BJ.