Hyperleukocytosis associated with pertussis: Two case reports.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

World Journal of Clinical Cases Pub Date : 2025-06-16 DOI:10.12998/wjcc.v13.i17.102207

Hong-Wu Han, Xi-Xia Wang, Ying Wang, Wei-Hua Zhang

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Abstract

Background: Pertussis is an acute respiratory infectious disease caused by Bordetella pertussis. Although the diphtheria-pertussis-tetanus vaccine is widely administered, there are still a number of patients with severe pertussis each year, which can lead to death, especially in infants and young children. Hyperleukocytosis is a factor related to the severity of pertussis and a risk factor for death. Reducing the leukocyte number by plasma exchange is a treatment method in clinical practice.

Case summary: Two children with pertussis with cough as the initial symptom, developed pneumonia during the course of the illness. White blood cell counts were significantly increased with the highest values of 87.34 × 10⁹/L and 55.46 × 10⁹/L. Following anti-infection, plasma exchange, and ventilator treatment, both children recovered.

Conclusion: Early identification of children with pertussis complicated with hyperleukocytosis and timely plasma exchange can improve the prognosis and reduce mortality.

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白细胞增多症与百日咳相关：2例报告。

背景：百日咳是一种由百日咳杆菌引起的急性呼吸道传染病。尽管广泛接种了白喉-百日咳-破伤风疫苗，但每年仍有一些严重百日咳患者，这可能导致死亡，特别是在婴儿和幼儿中。白细胞增多症是与百日咳严重程度相关的因素，也是死亡的危险因素。血浆交换法减少白细胞数量是临床上常用的治疗方法。病例总结：2例以咳嗽为首发症状的百日咳患儿，在发病过程中出现肺炎。白细胞计数显著升高，最高值分别为87.34 × 109/L和55.46 × 109/L。经抗感染、血浆置换和呼吸机治疗后，两名儿童均康复。结论：早期发现儿童百日咳合并白细胞增多症，及时调换血浆可改善预后，降低病死率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Clinical Cases Medicine-General Medicine

自引率

0.00%

发文量

3384

期刊介绍： The World Journal of Clinical Cases (WJCC) is a high-quality, peer reviewed, open-access journal. The primary task of WJCC is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of clinical cases. In order to promote productive academic communication, the peer review process for the WJCC is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCC are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in clinical cases.