Successful treatment of meglumine antimoniate in patient with cutaneous leishmaniasis with end-stage renal failure undergoing hemodialysis: a case report.

Abstract

Background: Cutaneous leishmaniasis is the most common form of leishmaniasis. Meglumine antimoniate is the first line of available treatment in developing countries. There is limited research on the renal effects of antimonial compounds.

Case presentation: A 25-year-old Arab male patient presented to the dermatology clinic with a 9-month history of multiple skin lesions. The patient had a history of end-stage renal failure. Physical examination of these lesions revealed ulcerated nodules that are painless and non-itchy located on the hands, forearms, feet, and neck. The lesions were diagnosed as cutaneous leishmaniasis tropica on the basis of the histopathology of a skin biopsy and the patient's region, which is endemic to female sandflies and this specific subtype cutaneous leishmaniasis. The patient started taking meglumine antimoniate intramuscular administration after the dialysis session at a dose of 750 mg/kg per week. The lesions showed partial to complete remission after 60 days of treatment without any meglumine antimoniate side effects. The patient has not experienced any relapse of leishmaniasis since kidney transplantation 6 years ago.

Conclusion: This case highlights knowledge gaps in the therapeutic approach for using meglumine antimoniate in patients with end-stage renal failure undergoing hemodialysis. The need for further research and clinical trials to establish clear guidelines is essential.