Clinical Data Registry Comparing Outcomes of Two Light Adjustable Lenses.

Abstract

Purpose: To compare the clinical performance of the light adjustable lenses (LAL) to the LAL+ with an increased central power to have broader depth of focus.

Setting: Private practice clinics.

Design: Prospective, non-randomized, non-masked, multi-center.

Methods: Clinical data collection registry of patients bilaterally implanted with the LAL or LAL+ (RxSight, Inc.). Outcome measures included subjective manifest refraction; monocular best corrected distance, intermediate and near visual acuity; binocular uncorrected distance, intermediate, and near visual acuity; and binocular uncorrected best focus visual acuity at differing contrast levels.

Results: 91.1% and 93.5% of LAL and LAL+ eyes had an MRSE within 0.50 D of target, respectively. 92.0% and 89.0% of LAL and LAL+ patients had a binocular uncorrected distance visual acuity (UCDVA) of 20/20 or better after adjustment, respectively. 86.0% and 93.0% of LAL and LAL+ patients had binocular uncorrected best focus visual acuity of J1 or better at 100% contrast, respectively. Distance corrected intermediate and near visual acuity was better with the LAL+ compared to the LAL, consistent with its further broadened depth of focus. Best corrected distance vision was only slightly reduced for LAL+ (1 letter), with both lenses achieving high levels.

Conclusions: Both the LAL and LAL+ achieved excellent refractive and binocular visual outcomes at distance, intermediate and near. The broadened depth of focus of the LAL+ was clinically evident and led to less anisometropia. The ability of patients to binocularly select and adjust their refraction according to their visual goal is a unique therapeutic approach to cataract refractive patients.