The Effects of Specific Gut Microbiota on Hyperuricemia - A Mendelian Randomization Analysis and Clinical Validation.

IF 3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-06-10 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S510384

Dilinuer Αikepa, Yi He, Wujin Chen, Meiting Liang, Yongkun Du, Xiaoyu Chen, Manxi Du, Yuqiu Zhu, Jianping Wang, Yuping Sun

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Abstract

Background: Hyperuricemia (HUA) is a metabolic disorder caused by an imbalance between uric acid (UA) production and excretion. It is closely associated with various diseases, including gout and kidney disease. The intestines play a significant role in UA excretion, and emerging evidence suggests that gut microbiota modulate UA excretion and degradation. However, the specific functional microbial biomarkers and their roles in HUA remain underexplored.

Methods: Based on this, we hypothesize that the Mendelian randomization (MR) analysis method can be used to identify and define microbial biomarkers associated with HUA. Accordingly, we conducted an MR study using gut microbiota data from 18,340 participants across 24 distinct cohorts, including 129 HUA patients and 352,232 controls, to investigate the causal relationship.

Results: We found that the genus Ruminococcus was linked to a lower risk of HUA, while the family Clostridiaceae was associated with a higher risk of HUA. Clinical validation showed that high Clostridiaceae and low Ruminococcus abundance could distinguish HUA patients from healthy individuals, and the predictive diagnostic efficacy of Clostridiaceae was better. The combined model further enhanced diagnostic accuracy.

Conclusion: Our findings provide important information on the micro-biome features of HUA and novel insights into the further determination of the roles of the involved microorganisms, providing a reference for disease diagnosis and the development of microbial therapies.

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特定肠道菌群对高尿酸血症的影响——孟德尔随机分析和临床验证。

背景：高尿酸血症（HUA）是一种由尿酸（UA）产生和排泄失衡引起的代谢性疾病。它与各种疾病密切相关，包括痛风和肾脏疾病。肠道在UA排泄中起着重要作用，新的证据表明肠道微生物群调节UA的排泄和降解。然而，具体的功能微生物生物标志物及其在HUA中的作用仍未得到充分研究。方法：基于此，我们假设孟德尔随机化（MR）分析方法可用于识别和定义与HUA相关的微生物生物标志物。因此，我们进行了一项MR研究，使用来自24个不同队列的18,340名参与者的肠道微生物群数据，包括129名HUA患者和352,232名对照，以调查因果关系。结果：我们发现Ruminococcus属与HUA的风险较低有关，而Clostridiaceae家族与HUA的风险较高有关。临床验证表明，高梭菌科和低瘤胃球菌丰度可以区分HUA患者和健康人群，且梭菌科的预测诊断效果更好。联合模型进一步提高了诊断准确率。结论：我们的研究结果为HUA的微生物组特征提供了重要信息，并为进一步确定相关微生物的作用提供了新的见解，为疾病诊断和微生物治疗的开发提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.