Administration of high-dose intravenous vitamin C in healthy dogs transiently leads to a false increase in portable blood glucose monitor and interstitial glucose monitor readings.
Joanna Lum, Angie Andrea Rincon, Elizabeth J Thomovsky, Paula A Johnson, Aimee C Brooks, Hsin-Yi Weng
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引用次数: 0
Abstract
Objective: To investigate the effects of high-dose IV vitamin C (HDIVC) on handheld portable blood glucose monitor (PBGM) and interstitial glucose monitor (IGM) readings in dogs.
Methods: 6 client-owned Border Collies with normal physical examinations and baseline bloodwork were enrolled in this prospective experimental study from November through December 2024. Glucose was measured via an IGM, PBGM, and laboratory blood glucose analyzer (LG) at time (T)-0, T1, T2, T3, T6, T12, T18, and T24 hours after HDIVC (200 mg/kg; ascorbic acid 500 mg/mL diluted 1:10 with sterile water, given over 30 minutes, IV).
Results: The median PBGM (T1, 189 mg/dL; T2, 138 mg/dL) and IGM (T1, high; T2, 321 mg/dL) readings were significantly higher than LG (T1, 76.5 mg/dL; T2, 93.5 mg/dL) at T1 and T2. The median IGM (183 mg/dL) readings were significantly higher than LG (99 mg/dL) at T3. There was no significant difference between modalities at T0 nor from T6 on. On consensus error grid analysis, all PBGM readings at T1 and 1 of 6 readings at T2 were clinically unacceptable. All IGM readings at T1 and T2 and 2 of 6 readings at T3 were clinically unacceptable.
Conclusions: A 200-mg/kg, IV, bolus of vitamin C in healthy dogs causes clinically significant elevations in PBGM and IGM glucose readings that normalize within 3 and 6 hours, respectively.
Clinical relevance: Avoid the use of PBGM and IGM until 3 and 6 hours, respectively, after HDIVC in healthy dogs.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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