Li Song, Yili Dai, Xin Zhou, Yan Tan, Zijie Zhou, Xing Zheng, Fei Zhao, Meifang Yang, Houchao Tao
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引用次数: 0
Abstract
Detergents are indispensable for membrane protein (MP) research, yet innovative designs are needed to meet the diverse requirements of MPs. Herein, anthracene-bridged detergents (ABDs) are presented, featuring a curved anthracene-based scaffold with a hydrophobic core and hydrophilic exterior. The modular synthesis of ABDs facilitates a systematic exploration of their structure-property relationships. Evaluation across representative G protein-coupled receptors demonstrates superior or comparable stabilization to conventional detergents. Notably, PP-ABD maintains complete homogeneity of A2AAR after heat shock and exhibits strong potential for electron microscopy applications. This study establishes ABDs as versatile and effective tools for MP research, offering valuable insights into the rational design of next-generation detergents.
期刊介绍：
ChemPlusChem is a peer-reviewed, general chemistry journal that brings readers the very best in multidisciplinary research centering on chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
Fully comprehensive in its scope, ChemPlusChem publishes articles covering new results from at least two different aspects (subfields) of chemistry or one of chemistry and one of another scientific discipline (one chemistry topic plus another one, hence the title ChemPlusChem). All suitable submissions undergo balanced peer review by experts in the field to ensure the highest quality, originality, relevance, significance, and validity.
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