Precision medicine and Treat-to-Target approach in atopic dermatitis: enhancing personalized care and outcomes

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia Pub Date : 2025-06-18 DOI:10.1016/j.abd.2025.501135

Dan Hartmann , Catalina Retamal , Fernando Valenzuela

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引用次数: 0

Abstract

Background

Atopic Dermatitis (AD) is a chronic inflammatory skin disease affecting a significant portion of the global population. While conventional treatments effectively control and manage symptoms, there is a growing need for more personalized and precise approaches for patients. Precision medicine has emerged as a promising therapeutic strategy that tailors treatment to the individual characteristics of each patient. Complementing this, the Treat-to-Target (T2T) strategy sets specific clinical goals and involves continuous monitoring and treatment adjustments based on real-time patient responses and biomarker data.

Objectives

This review aims to explore the latest advancements in precision medicine and the T2T strategy for AD.

Methods

A comprehensive literature review was conducted to identify the most recent studies and advancements in precision medicine and the T2T strategy for AD.

Results

Recent studies highlight the effectiveness of precision medicine in achieving sustained remission and improving the quality of life for patients. The T2T strategy was shown to be effective in preventing exacerbations and adapting treatments based on real-time patient responses and biomarker data.

Study limitations

The lack of a consensus on the clinical implementation of precision medicine and T2T, limited longitudinal studies validating long-term outcomes, challenges in stratifying patients due to biomarker heterogeneity, and barriers to integrating emerging diagnostic technologies into routine practice.

Conclusions

Precision medicine and the T2T strategy represent significant advancements in the management of AD. These approaches offer the potential for more personalized, effective, and adaptive treatment protocols, leading to improved patient outcomes. Continuous research and development in these areas are essential to fully realize their potential and integrate them into routine clinical practice.

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特应性皮炎的精准医疗和靶向治疗方法：增强个性化护理和结果

背景：过敏性皮炎（AD）是一种慢性炎症性皮肤病，影响着全球很大一部分人群。虽然传统治疗有效地控制和管理症状，但越来越需要为患者提供更个性化和更精确的方法。精准医疗已经成为一种很有前途的治疗策略，它根据每个病人的个体特征量身定制治疗。与此相辅相成的是，T2T策略设定了具体的临床目标，并涉及基于实时患者反应和生物标志物数据的持续监测和治疗调整。目的探讨精准医学和T2T治疗AD的最新进展。方法通过文献综述，总结精准医学和T2T治疗AD的最新研究进展。结果最近的研究强调了精准医疗在实现持续缓解和改善患者生活质量方面的有效性。T2T策略在预防恶化和根据实时患者反应和生物标志物数据调整治疗方面被证明是有效的。研究局限性：对精准医学和T2T的临床实施缺乏共识，验证长期结果的纵向研究有限，由于生物标志物异质性，在对患者进行分层方面存在挑战，以及将新兴诊断技术整合到常规实践中的障碍。结论精准医学和T2T策略在AD的治疗中取得了重大进展。这些方法提供了更加个性化、有效和适应性治疗方案的潜力，从而改善了患者的预后。这些领域的持续研究和发展对于充分发挥其潜力并将其纳入常规临床实践至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anais brasileiros de dermatologia DERMATOLOGY-

CiteScore

2.40

自引率

0.00%

发文量

184

审稿时长

32 days

期刊介绍： The journal is published bimonthly and is devoted to the dissemination of original, unpublished technical-scientific study, resulting from research or reviews of dermatological topics and related matters. Exchanges with other publications may be accepted.