Pulmonary fungal infection caused by Rhizopus microsporus in type II diabetic patient:A case report

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-06-11 DOI:10.1016/j.diagmicrobio.2025.116953

Huan Chen , Fangfang Ruan , Weiwei Wu , Jia Liu , Zhiguo Wang , Xiaobin Xu , Yigen Liu , Sun Wu , Jun Zhou , Jinxiu Ma

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Abstract

Pulmonary fungal infections are invasive fungal diseases with high mortality, particularly in immunocompromised patients. This case report describes a patient with type II diabetes mellitus who developed a pulmonary fungal infection. The patient presented with a one-week history of paroxysmal cough and expectoration of yellowish-white, purulent sputum following exposure to cold temperatures. Initial empirical antiviral therapy failed to yield any clinical improvement Subsequent chest computed tomography (CT) scans revealed irregular areas of increased density in the left lower lung, while metagenomic next-generation sequencing (mNGS) identified the infection as caused by Rhizopus microspores. The patient was treated with intravenous amphotericin B and showed clinical improvement without side effects during follow-up. This case highlighted the potential of mNGS as an adjunctive diagnostic tool for rare pathogen infections, especially in immunocompromised patients where conventional microbiological methods may be inconclusive.

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小孢子根霉致2型糖尿病患者肺部真菌感染1例

肺部真菌感染是侵袭性真菌疾病，死亡率高，特别是在免疫功能低下的患者中。本病例报告描述了一个2型糖尿病患者并发肺部真菌感染。患者暴露于低温后，有一周的阵发性咳嗽和黄白色化脓痰。最初的经经验抗病毒治疗未能产生任何临床改善，随后的胸部计算机断层扫描（CT）显示左下肺密度增加的不规则区域，而新一代元基因组测序（mNGS）确定感染是由根霉小孢子引起的。患者给予两性霉素B静脉注射治疗，随访期间临床改善，无不良反应。该病例强调了mNGS作为罕见病原体感染的辅助诊断工具的潜力，特别是在传统微生物学方法可能不确定的免疫功能低下患者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.