Bioadhesive polymers in transdermal formulations for skin disorders

IF 4.2 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2025-06-02 DOI:10.1016/j.coph.2025.102544

Sanjeevani R. Desai , Durgacharan A. Bhagwat , Anil Kumar Singh , Rupali Baban Kumbhar , Jiyauddin Khan

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Abstract

Transdermal drug delivery (TDD) offer numerous advantages over conventional routes, including improved patient compliance and sustained drug release. Bioadhesive polymers play a crucial role in TDD, enhancing drug retention and controlled release. This review explores the applications of bioadhesive polymers in transdermal formulations for skin disorders, focusing on their adhesion mechanisms, structural modifications, and therapeutic potential. Natural bioadhesives like alginate and chitosan demonstrate anti-inflammatory, antimicrobial, and wound-healing properties, while synthetic polymers such as polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) offer controlled drug release and mechanical stability. Despite their advantages, challenges such as adhesion failure, moisture sensitivity, and limited macromolecular drug delivery persist. Recent innovations, including self-healing hydrogels, nanofiber-based transdermal systems, and enzymatic drug carriers, present new opportunities for dermatological applications.

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用于皮肤疾病的透皮配方中的生物粘合剂聚合物

经皮给药（TDD）提供了许多优于传统途径，包括提高患者依从性和持续的药物释放。生物黏附聚合物在TDD中起着至关重要的作用，增强了药物的保留和控释。本文综述了生物黏附聚合物在皮肤疾病透皮配方中的应用，重点介绍了它们的黏附机制、结构修饰和治疗潜力。海藻酸盐和壳聚糖等天然生物粘合剂具有抗炎、抗菌和伤口愈合的特性，而聚乙烯醇（PVA）和聚乙烯吡咯烷酮（PVP）等合成聚合物具有可控的药物释放和机械稳定性。尽管它们具有优势，但诸如粘附失败、水分敏感性和有限的大分子药物递送等挑战仍然存在。最近的创新，包括自修复水凝胶、纳米纤维透皮系统和酶促药物载体，为皮肤病学应用提供了新的机会。

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.