A review on recent insights on cardiovascular diseases drug design using natural products and in silico studies

IF 1.2 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science Pub Date : 2025-06-13 DOI:10.1016/j.kjs.2025.100438

Sylvester Nnaemeka Ugariogu , Naser F. Al-Tannak , Samya Sh Alenezi

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引用次数: 0

Abstract

Cardiovascular diseases (CVDs), which are among the leading causes of morbidity and mortality, are strongly associated with unhealthy eating habits. Compounds originating from plants, natural products, and balanced diets have been identified as potential remedies for CVDs. Natural products that improve cardiovascular health may include fruits, vegetables, spices, herbs, propolis, honey, and red wine. This review focused on articles published from 2015 onwards from Scopus, Google Scholar, and Pubmed, highlighting key studies on natural products and in silico research for managing CVDs, including their biosynthesis, mode of action, and origins. Overall, this assessment indicated that in silico research and natural products have been useful in providing insightful cures for some CVDs, but they still have a lot of unrealized potential. Some of the target proteins and protein databank identification numbers that may be utilized in in silico research for cardiovascular disorders were displayed.

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综述利用天然产物和计算机研究的心血管疾病药物设计的最新见解

心血管疾病是发病率和死亡率的主要原因之一，与不健康的饮食习惯密切相关。来自植物、天然产物和均衡饮食的化合物已被确定为心血管疾病的潜在补救措施。改善心血管健康的天然产品可能包括水果、蔬菜、香料、草药、蜂胶、蜂蜜和红酒。本综述集中于Scopus、谷歌Scholar和Pubmed自2015年以来发表的文章，重点介绍了cvd管理的天然产物和计算机研究的关键研究，包括其生物合成、作用方式和起源。总的来说，这一评估表明，硅研究和天然产物在为一些心血管疾病提供有见地的治疗方面是有用的，但它们仍有许多未实现的潜力。显示了一些可用于心血管疾病计算机研究的靶蛋白和蛋白质数据库识别码。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kuwait Journal of Science MULTIDISCIPLINARY SCIENCES-

CiteScore

1.60

自引率

28.60%

发文量

132

期刊介绍： Kuwait Journal of Science (KJS) is indexed and abstracted by major publishing houses such as Chemical Abstract, Science Citation Index, Current contents, Mathematics Abstract, Micribiological Abstracts etc. KJS publishes peer-review articles in various fields of Science including Mathematics, Computer Science, Physics, Statistics, Biology, Chemistry and Earth & Environmental Sciences. In addition, it also aims to bring the results of scientific research carried out under a variety of intellectual traditions and organizations to the attention of specialized scholarly readership. As such, the publisher expects the submission of original manuscripts which contain analysis and solutions about important theoretical, empirical and normative issues.