Advances in terahertz biochemical sensing analysis: metasensor enhancement, multi-parameter characterization, and nanomaterial modification

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-06-13 DOI:10.1016/j.trac.2025.118342

Peng Shen , Yunyun Ji , Liang Ma , Jixin Feng , Yiferng Li , Chengwei Song , Fan Yang , Xianghui Wang , Fei Fan , Shengjiang Chang

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引用次数: 0

Abstract

Terahertz (THz) spectrum features low photon energy and non-ionization, and supports weak molecular interaction and macromolecular vibration within its range, making it especially suitable for rapid, sensitive, and non-destructive biochemical molecular sensing. However, it still has certain limitations in recognizing the configurations and conformations of some chiral molecules. Therefore, it is necessary to combine polarization and chiral spectrum for sensing characterization to obtain relevant information comprehensively and accurately. In this review, we delve into the metasensor, involving the multi-parameter sensing characterization strategy beyond the traditional amplitude/frequency detection dimension, and integrating the nanomaterial modification technologies like graphene and metal nanoparticles to build a composite metasensor system. We focus on the sensing application of the THz spectrum in various biochemical substances based on metasensor enhancement, multi-parameter characterization, and nanomaterial modification. Besides, the development trend and challenges of THz metasensors are prospected.

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太赫兹生化传感分析的进展：元传感器增强、多参数表征和纳米材料修饰

太赫兹（THz）光谱具有光子能量低、不电离的特点，在其范围内支持弱分子相互作用和大分子振动，特别适用于快速、灵敏、无损的生化分子传感。然而，它在识别某些手性分子的构型和构象方面仍有一定的局限性。因此，有必要将极化和手性光谱相结合进行传感表征，以全面准确地获取相关信息。在本文中，我们深入研究了超传感器，涉及超越传统幅度/频率检测维度的多参数传感表征策略，并整合石墨烯和金属纳米颗粒等纳米材料改性技术构建复合超传感器系统。基于超传感器增强、多参数表征和纳米材料修饰，重点研究太赫兹光谱在各种生化物质中的传感应用。展望了太赫兹超传感器的发展趋势和面临的挑战。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.