Impact of atmospheric pressure DBD plasma treatment on the biodegradability, hydrophilicity, and mechanical properties of PVA/PEG/Chitosan/HA nanofibers for bone tissue engineering

IF 3.7 Q1 CHEMISTRY, ANALYTICAL

Talanta Open Pub Date : 2025-06-18 DOI:10.1016/j.talo.2025.100501

Hartatiek , M.I. Wuriantika , Yudyanto , A. Taufiq , M. Diantoro , Y. Yusuf , M. Taufik , J.F. Fatriansyah

{"title":"Impact of atmospheric pressure DBD plasma treatment on the biodegradability, hydrophilicity, and mechanical properties of PVA/PEG/Chitosan/HA nanofibers for bone tissue engineering","authors":"Hartatiek , M.I. Wuriantika , Yudyanto , A. Taufiq , M. Diantoro , Y. Yusuf , M. Taufik , J.F. Fatriansyah","doi":"10.1016/j.talo.2025.100501","DOIUrl":null,"url":null,"abstract":"<div><div>The effectiveness of scaffolds in supporting bone tissue regeneration is highly dependent on surface modification. Atmospheric pressure dielectric barrier (DBD) plasma treatment offers a practical method that offers simplicity, time efficiency, cost effectiveness, and reliable results. In this study, nanofiber scaffolds composed of PVA, PEG, chitosan, and hydroxyapatite were fabricated using electrospinning and treated with DBD plasma at varying distances. Optical emission spectroscopy (OES) confirmed the presence of reactive species such as OH radicals, nitrogen (N<sub>2</sub>), and nitrogen ions (N<sub>2</sub><sup>+</sup>). These species caused changes in surface morphology, including an increase in fiber diameter. These surface morphological modifications were associated with mechanical properties and hydrophilicity. Furthermore, scaffolds treated at a distance of 1.5 mm showed a degradation rate of up to 70 % after three weeks. The results highlight the potential of DBD plasma treatment to optimize the performance of bone tissue engineering scaffolds.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"12 ","pages":"Article 100501"},"PeriodicalIF":3.7000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Talanta Open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666831925001031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

The effectiveness of scaffolds in supporting bone tissue regeneration is highly dependent on surface modification. Atmospheric pressure dielectric barrier (DBD) plasma treatment offers a practical method that offers simplicity, time efficiency, cost effectiveness, and reliable results. In this study, nanofiber scaffolds composed of PVA, PEG, chitosan, and hydroxyapatite were fabricated using electrospinning and treated with DBD plasma at varying distances. Optical emission spectroscopy (OES) confirmed the presence of reactive species such as OH radicals, nitrogen (N₂), and nitrogen ions (N₂⁺). These species caused changes in surface morphology, including an increase in fiber diameter. These surface morphological modifications were associated with mechanical properties and hydrophilicity. Furthermore, scaffolds treated at a distance of 1.5 mm showed a degradation rate of up to 70 % after three weeks. The results highlight the potential of DBD plasma treatment to optimize the performance of bone tissue engineering scaffolds.

Abstract Image

查看原文本刊更多论文

常压DBD等离子体处理对骨组织工程用PVA/PEG/壳聚糖/HA纳米纤维的生物降解性、亲水性和力学性能的影响

支架支持骨组织再生的有效性高度依赖于表面修饰。大气压介质阻挡（DBD）等离子体处理提供了一种实用的方法，具有简单、省时、成本效益和可靠的结果。在本研究中，采用静电纺丝法制备了聚乙烯醇、聚乙二醇、壳聚糖和羟基磷灰石组成的纳米纤维支架，并用DBD等离子体在不同距离上处理。光学发射光谱（OES）证实了OH自由基、氮（N2）和氮离子（N2+）等活性物质的存在。这些物种引起了表面形态的变化，包括纤维直径的增加。这些表面形态的改变与机械性能和亲水性有关。此外，在1.5 mm距离处处理的支架在三周后的降解率高达70%。结果表明，DBD等离子体处理在优化骨组织工程支架性能方面具有潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊