Schizophrenia, Antipsychotic Drugs, and Risk of Breast Cancer.

IF 4.5 2区 医学 Q1 PSYCHIATRY
Chittaranjan Andrade
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引用次数: 0

Abstract

Breast cancer is the commonest form of cancer among women. Literature suggests that women with schizophrenia are less likely to be screened for breast cancer and that, among women with schizophrenia who develop breast cancer, mortality rates are higher. This article examines recent meta-analyses and recent observational studies on the risk of breast cancer in women with schizophrenia, especially in the context of treatment with first generation and second generation antipsychotic (FGA, SGA) drugs. This article also examines the most recent observational study in detail to help readers better understand how to critically appraise this and, by extension, other studies in the field. In summary, studies in the field suggest that there is a small but statistically significant increase in the risk of breast cancer in women with schizophrenia relative to women without psychiatric disorders as well as relative to women with other psychiatric disorders. Women who appear to be most at risk are those in the perimenopausal age range and those with several years of exposure to FGA or prolactin raising antipsychotics. Whereas the possibility of residual confounding in observational studies precludes ascribing a causal role for antipsychotics, given that FGA and prolactin-raising SGA are associated with other adverse effects, it seems reasonable, wherever possible, to prefer SGA over FGA, and prolactin-sparing over prolactin-raising antipsychotics. Women with schizophrenia, and especially those who use prolactin raising antipsychotics for long periods, should be monitored for the risk of breast cancer as a special part of monitoring general health; and modifiable risk factors for breast cancer should be addressed through appropriate behavioral and pharmacological interventions. Women with schizophrenia comprise a vulnerable population, and their medical health should not be neglected even when caring for their mental health absorbs attention and time. Suggestions are provided for directions for future research.

精神分裂症、抗精神病药物和乳腺癌风险。
乳腺癌是女性中最常见的癌症。文献表明,患有精神分裂症的女性不太可能接受乳腺癌筛查,而在患有精神分裂症的女性中,患乳腺癌的死亡率更高。本文研究了最近的荟萃分析和最近的观察性研究,研究了精神分裂症女性患乳腺癌的风险,特别是在第一代和第二代抗精神病药物(FGA, SGA)治疗的背景下。本文还详细考察了最新的观察性研究,以帮助读者更好地理解如何批判性地评估这一研究,并进一步扩展到该领域的其他研究。总之,该领域的研究表明,与没有精神疾病的女性以及患有其他精神疾病的女性相比,患有精神分裂症的女性患乳腺癌的风险有一个小而显著的统计学意义。最危险的女性是围绝经期的女性,以及多年服用促排卵药物的女性。鉴于观察性研究中残留混淆的可能性排除了抗精神病药物的因果作用,鉴于FGA和催乳素升高SGA与其他不良反应相关,似乎合理的是,只要可能,选择SGA而不是FGA,选择节省催乳素的抗精神病药物而不是催乳素升高的抗精神病药物。患有精神分裂症的妇女,特别是那些长期使用催乳素升高的抗精神病药物的妇女,应作为监测一般健康的一个特殊部分,监测其患乳腺癌的风险;乳腺癌的可改变的危险因素应该通过适当的行为和药物干预来解决。患有精神分裂症的妇女是弱势群体,即使照顾她们的精神健康占用了人们的注意力和时间,也不应忽视她们的医疗健康。并对今后的研究方向提出了建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Clinical Psychiatry
Journal of Clinical Psychiatry 医学-精神病学
CiteScore
7.40
自引率
1.90%
发文量
0
审稿时长
3-8 weeks
期刊介绍: For over 75 years, The Journal of Clinical Psychiatry has been a leading source of peer-reviewed articles offering the latest information on mental health topics to psychiatrists and other medical professionals.The Journal of Clinical Psychiatry is the leading psychiatric resource for clinical information and covers disorders including depression, bipolar disorder, schizophrenia, anxiety, addiction, posttraumatic stress disorder, and attention-deficit/hyperactivity disorder while exploring the newest advances in diagnosis and treatment.
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