Decoding force-transmission linkages for therapeutic targeting and engineering.

IF 6.6 3区 医学 Q1 ENGINEERING, BIOMEDICAL
APL Bioengineering Pub Date : 2025-06-13 eCollection Date: 2025-06-01 DOI:10.1063/5.0267032
Jingzhun Liu, Yunxin Deng, Jie Yan
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引用次数: 0

Abstract

Mechanosensing and mechanotransduction enable cells to perceive and respond to mechanical forces, underpinning essential physiological processes and disease pathways. Central to these phenomena are force-transmission supramolecular linkages, which undergo structural transitions and regulate signaling proteins in response to mechanical stimuli. This review examines the mechanisms of these force-bearing linkages, focusing on force duration, dictated by the stability of protein-protein interfaces, and force-dependent mechanical structural changes of force-bearing domains in the linkage, which activates or deactivates mechanosensing domains. We discuss the emerging potential of these linkages as pharmaceutical targets, exploring drugs and peptides designed to modulate these mechanical properties. In addition, we highlight the application of artificial intelligence in protein engineering to enhance therapeutic precision by dynamically tuning these mechanosensing characteristics. Our synthesis of current findings and future perspectives aims to inform novel approaches to drug design and inspire future research in the field of mechanomedicine.

解码力-传输联系的治疗靶向和工程。
机械传感和机械转导使细胞能够感知和响应机械力,支撑基本的生理过程和疾病途径。这些现象的核心是力传递超分子连接,它经历结构转变并调节信号蛋白以响应机械刺激。这篇综述研究了这些受力连接的机制,重点关注由蛋白质-蛋白质界面稳定性决定的力持续时间,以及连接中受力结构域的力依赖机械结构变化,这些变化会激活或禁用机械传感结构域。我们讨论了这些连接作为药物靶点的新兴潜力,探索了设计用于调节这些机械性能的药物和肽。此外,我们强调人工智能在蛋白质工程中的应用,通过动态调整这些机械传感特性来提高治疗精度。我们对当前发现和未来观点的综合旨在为药物设计提供新的方法,并启发机械医学领域的未来研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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