Digital biomarkers of ageing for monitoring physiological systems in community-dwelling adults

IF 14.6 Q1 GERIATRICS & GERONTOLOGY

Lancet Healthy Longevity Pub Date : 2025-06-01 DOI:10.1016/j.lanhl.2025.100725

Jessica K Lu MEng , Weilan Wang PhD , Muhammad Daniel Azlan Mahadzir PhD , Jesse R Poganik PhD , Mahdi Moqri PhD , Chiara Herzog PhD , Eric Verdin MD , Vittorio Sebastiano PhD , Prof Vadim N Gladyshev PhD , Andrea B Maier MD

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引用次数: 0

Abstract

Digital health technologies are transforming health care and personal health management by providing quantifiable data on physiological, behavioural, and environmental health parameters using digital biomarkers. This narrative review classified, characterised, and evaluated digital biomarkers of ageing across ten physiological systems to explore the applications of these biomarkers in research and clinical practice. The systematic search identified minimally invasive or non-invasively measured digital biomarkers suitable for longitudinal studies and practical use by community-dwelling adults. The digital biomarkers were classified according to their physiological system, characterised by their capture methods, and evaluated based on the following criteria: validity (age-associated, function-associated, and mortality-associated), generalisability, responsiveness to interventions, associations with clinical outcomes, and cost-effectiveness in large-scale settings. Digital biomarkers of ageing were found across eight physiological systems. Registered clinical trials that used these digital biomarkers as outcomes were also identified. Continued research and technological advancements are crucial for maximising the potential of digital biomarkers in promoting healthy ageing and longevity.

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用于监测社区居住成年人生理系统的衰老数字生物标志物。

数字卫生技术通过使用数字生物标志物提供关于生理、行为和环境健康参数的可量化数据，正在改变卫生保健和个人健康管理。这篇叙述性综述分类、表征和评估了10个生理系统中衰老的数字生物标志物，以探索这些生物标志物在研究和临床实践中的应用。系统搜索确定了适合纵向研究和社区居住成年人实际使用的微创或非侵入性测量数字生物标志物。数字生物标志物根据其生理系统进行分类，以其捕获方法为特征，并根据以下标准进行评估：有效性（与年龄相关、与功能相关和与死亡率相关）、普遍性、对干预措施的反应性、与临床结果的关联以及大规模环境中的成本效益。在8个生理系统中发现了衰老的数字生物标志物。使用这些数字生物标志物作为结果的注册临床试验也被确定。持续的研究和技术进步对于最大限度地发挥数字生物标志物在促进健康老龄化和长寿方面的潜力至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lancet Healthy Longevity GERIATRICS & GERONTOLOGY-

CiteScore

16.30

自引率

2.30%

发文量

192

审稿时长

12 weeks

期刊介绍： The Lancet Healthy Longevity, a gold open-access journal, focuses on clinically-relevant longevity and healthy aging research. It covers early-stage clinical research on aging mechanisms, epidemiological studies, and societal research on changing populations. The journal includes clinical trials across disciplines, particularly in gerontology and age-specific clinical guidelines. In line with the Lancet family tradition, it advocates for the rights of all to healthy lives, emphasizing original research likely to impact clinical practice or thinking. Clinical and policy reviews also contribute to shaping the discourse in this rapidly growing discipline.