The gut virome in association with the bacteriome in gastrointestinal diseases and beyond: roles, mechanisms, and clinical applications.

IF 5.1 4区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Precision Clinical Medicine Pub Date : 2025-05-28 eCollection Date: 2025-06-01 DOI:10.1093/pcmedi/pbaf010

Zhiyang Feng, Elke Burgermeister, Anna Philips, Tao Zuo, Weijie Wen

引用次数: 0

Abstract

The gut virome, an essential component of the intestinal microbiome, constitutes ∼0.1% of the total microbial biomass but contains a far greater number of particles than bacteria, with phages making up 90%-95% of this virome. This review systematically examines the developmental patterns of the gut virome, focusing on factors influencing its composition, including diet, environment, host genetics, and immunity. Additionally, it explores the gut virome's associations with various diseases, its interactions with gut bacteria and the immune system, and its emerging clinical applications.

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肠道病毒组与细菌组在胃肠道疾病及其他疾病中的作用、机制和临床应用

肠道病毒组是肠道微生物组的重要组成部分，占微生物总生物量的0.1%，但其颗粒数量远高于细菌，其中噬菌体占该病毒组的90%-95%。本文系统地研究了肠道病毒的发育模式，重点研究了影响其组成的因素，包括饮食、环境、宿主遗传和免疫。此外，它还探讨了肠道病毒与各种疾病的关联，它与肠道细菌和免疫系统的相互作用，以及它的新兴临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Precision Clinical Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

10.80

自引率

0.00%

发文量

审稿时长

5 weeks

期刊介绍： Precision Clinical Medicine (PCM) is an international, peer-reviewed, open access journal that provides timely publication of original research articles, case reports, reviews, editorials, and perspectives across the spectrum of precision medicine. The journal's mission is to deliver new theories, methods, and evidence that enhance disease diagnosis, treatment, prevention, and prognosis, thereby establishing a vital communication platform for clinicians and researchers that has the potential to transform medical practice. PCM encompasses all facets of precision medicine, which involves personalized approaches to diagnosis, treatment, and prevention, tailored to individual patients or patient subgroups based on their unique genetic, phenotypic, or psychosocial profiles. The clinical conditions addressed by the journal include a wide range of areas such as cancer, infectious diseases, inherited diseases, complex diseases, and rare diseases.