Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study.

IF 5.4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

World Journal of Gastroenterology Pub Date : 2025-05-07 DOI:10.3748/wjg.v31.i17.105281

Yan-Ping Wu, Jia-Xuan Zhou, Hong-Bo Wu, Di-Ping Wu, Ling-Zhi Qin, Bin Qin, Xiao-Yu Xu, Saleh Abdulaziz Abdulgani Yehya, Yan Cheng

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引用次数: 0

Abstract

Background: Reflux hypersensitivity (RH) constitutes roughly 14% of patients with heartburn and 34% of those with refractory heartburn, yet it is inadequately comprehended.

Aim: To investigate the clinical characteristics and risk factors associated with RH.

Methods: We conducted a retrospective analysis of 109 patients with RH and 384 healthy controls from three medical centers between January 2022 and December 2023. Comprehensive data encompassing symptoms, motility, impedance-pH monitoring, and psychological evaluations were collected.

Results: RH patients encountered a greater frequency of weakly acidic reflux (WAR) events compared to acidic reflux or nonacidic reflux (NAR) events. Upright reflux time (1.22%) exceeds supine reflux time (0.54%) (P < 0.05). Extraesophageal symptoms were more prevalent among younger patients and those with elevated NAR (P < 0.05). The acidic reflux, WAR, NAR, and peristaltic contraction break length in male patients exceeded those in female patients (P < 0.05). Age [odds ratio (OR) = 5.633], hiatal hernia (OR = 13.103), and anxiety (OR = 17.342) constituted independent risk factors for RH.

Conclusion: WAR and NAR are pivotal in RH. Patients with increased NAR are more likely to experience extraesophageal symptoms. Age, hiatal hernia, and anxiety are significant independent risk factors for RH.

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食管反流超敏反应的临床特点及危险因素：一项多中心研究

背景：反流超敏反应（RH）约占胃灼热患者的14%，占难治性胃灼热患者的34%，但对其了解尚不充分。目的：探讨RH的临床特点及相关危险因素。方法：对2022年1月至2023年12月来自3个医疗中心的109例RH患者和384例健康对照进行回顾性分析。收集了包括症状、运动、阻抗- ph监测和心理评估在内的综合数据。结果：与酸性反流或非酸性反流（NAR）事件相比，RH患者发生弱酸性反流（WAR）事件的频率更高。直立反流时间（1.22%）超过仰卧反流时间（0.54%）（P < 0.05）。食管外症状在年轻患者和NAR升高患者中更为普遍（P < 0.05）。男性患者胃酸反流、WAR、NAR、蠕动收缩断裂长度均高于女性患者（P < 0.05）。年龄[优势比(OR) = 5.633]、裂孔疝（OR = 13.103）、焦虑（OR = 17.342）是RH的独立危险因素。结论：WAR和NAR在RH中起关键作用。NAR升高的患者更有可能出现食管外症状。年龄、裂孔疝和焦虑是RH的重要独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

7.80

自引率

4.70%

发文量

464

审稿时长

2.4 months

期刊介绍： The primary aims of the WJG are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in gastroenterology and hepatology.