Bandavirus dabieense: A review of epidemiology, clinical characteristics, pathophysiology, treatment and prevention.

Abstract

Bandavirus dabieense (commonly known as severe fever with thrombocytopenia syndrome virus, SFTSV) infection leads to severe fever with thrombocytopenia syndrome (SFTS), which is an emerging tick-borne natural focus disease discovered in middle-eastern China. SFTS is characterized by fever with thrombocytopenia, and patients' main clinical manifestations are leucopenia, elevated serum liver enzymes, and multiple organ failure. Ticks are considered as carriers of SFTSV transmission, and Haemaphysalis longicornalis is considered the main vector tick. SFTSV is disseminated through the migration or movement of tick-carrying migratory birds and other animal hosts. With changes in climate and environment, the habitat of ticks such as haemaphysalis longicornalis are continuously expanding, coupled with the diverse animal host species of the ticks. SFTS is evolving into a serious global public safety issue. In the absence of specific treatments and vaccines still being developed, monitoring and vector control are crucial for curbing the spread of SFTSV. Here, based on the existing literature, we reviewed the epidemiology, infection mechanism, clinical characteristics, diagnosis, prevention and clinical treatment of SFTSV to enhance the understanding of the SFTSV, with the aim of providing a theoretical basis guidance for the government and relevant institutions to prevent and control the further spread of SFTSV.