Immediate Neuroplastic Changes in the Cortex After iTBS on the Cerebellum of Stroke Patients: A Preliminary fNIRS Study.

IF 3.1 4区医学 Q2 Medicine

Neural Plasticity Pub Date : 2025-06-06 eCollection Date: 2025-01-01 DOI:10.1155/np/1362222

Shuo Xu, Shaofan Chen, Ningling Chen, Zhengcong Zhang, Chenfang Liang, Hongwei Huang, Huijie Zou, Haoqing Jiang

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Abstract

Background and Purpose: Intermittent theta-burst stimulation (iTBS) targeting the cerebellum represents a promising therapeutic approach, demonstrating efficacy in the rehabilitation of motor and cognitive impairments after stroke. This study aims to evaluate the real-time and immediate effects of cerebellar iTBS on the cerebral cortex of stroke patients. Methods: This study was conducted in a crossover design, initiating with sham-iTBS followed by iTBS after a 24-h washout period. The functional near-infrared spectroscopy (fNIRS) was applied to observe cortical activation from cerebellar iTBS in stroke patients and changes in resting-state functional connectivity (FC) and amplitude of low-frequency fluctuations (ALFF) poststimulation. Results: Compared to sham stimulation, significant enhancement of cortical activation was observed in the left dorsolateral prefrontal cortex (DLPFC; Channel 26, t = 2.47, p=0.036, Cohen's d = 0.783) and left primary motor cortex (PMC; Channel 61, t = 2.88, p=0.018, Cohen's d = 0.907; Channel 62, t = 2.62, p=0.028, Cohen's d = 0.826). Compared to the resting period after sham-iTBS, the resting period following iTBS demonstrated significantly enhanced FC between the temporal cortex (TC) and the somatosensory cortex (SSC) (p=0.029), as well as between the frontal eye field (FEF) and the PMC (p=0.031). Additionally, the ALFF value of the medial superior frontal gyrus (SFGmed) also increased significantly during the resting period after iTBS (Channel 20, t = 5.79, p=0.027, Cohen's d = 0.63). Conclusion: The application of iTBS to the cerebellum significantly enhances the activation of cognitive and motor areas in the cerebral cortex. Additionally, improved FC between brain regions and increased spontaneous neuronal activity were observed following stimulation. These findings reveal the potential mechanisms by which cerebellar iTBS may facilitate functional recovery in stroke patients.

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脑卒中患者小脑iTBS后皮层的即时神经可塑性改变：一项初步的近红外光谱研究。

背景与目的：针对小脑的间歇性θ -爆发刺激（iTBS）是一种很有前途的治疗方法，在卒中后运动和认知障碍的康复中显示出疗效。本研究旨在评估脑卒中患者小脑iTBS对大脑皮层的实时和即时影响。方法：本研究采用交叉设计，首先进行假iTBS，然后在24小时的洗脱期后进行iTBS。应用功能近红外光谱（fNIRS）观察脑卒中患者脑iTBS皮层激活及静息状态功能连通性（FC）和低频波动幅度（ALFF）的变化。结果：与假刺激相比，左背外侧前额叶皮层(DLPFC；26通道，t = 2.47, p=0.036, Cohen’s d = 0.783)和左初级运动皮层(PMC；频道61年,t = 2.88, p = 0.018,科恩的d = 0.907;频道62年,t = 2.62, p = 0.028,科恩的d = 0.826)。与假iTBS后静息期相比，iTBS后静息期颞叶皮层（TC）与体感皮层（SSC）之间、额叶视野（FEF）与前脑区（PMC）之间的FC显著增强（p=0.029）。此外，iTBS后静息期额叶内侧上回（SFGmed）的ALFF值也显著升高（20通道，t = 5.79, p=0.027, Cohen’s d = 0.63）。结论：iTBS对小脑的作用显著增强了大脑皮层认知区和运动区的激活。此外，刺激后观察到脑区之间的FC改善和自发神经元活动增加。这些发现揭示了小脑iTBS促进脑卒中患者功能恢复的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neural Plasticity Neuroscience-Neurology

CiteScore

5.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.