Building blocks for lung regeneration: Stem cells and niches

IF 6.5 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecules and Cells Pub Date : 2025-06-13 DOI:10.1016/j.mocell.2025.100241

Hyeyoung Lee , Chae Won Lim , Woo Ram Lee , Ji Eun Park , Da Yeon Yu , Jinwook Choi

{"title":"Building blocks for lung regeneration: Stem cells and niches","authors":"Hyeyoung Lee , Chae Won Lim , Woo Ram Lee , Ji Eun Park , Da Yeon Yu , Jinwook Choi","doi":"10.1016/j.mocell.2025.100241","DOIUrl":null,"url":null,"abstract":"<div><div>The respiratory system is an essential organ that performs gas exchange through the blood circulation in mammals. Unlike other organs, the lungs are directly exposed to the external environment, including particulate matter, cigarette smoke, and various pollutants, and are therefore, highly susceptible to damage. The lungs retain regional-specific stem/progenitor cells that quickly mobilize to replace the damaged epithelium. Accumulating evidences suggest that fate decision of stem cells relies on regulatory programs integrated by niches constituting the microenvironment providing diverse signals that regulate stem cell behavior. Therefore, understanding cellular diversity and precise interaction between stem cells and their respective niches is crucial to understand how tissue recovers homeostasis after injury. Here, in this review, we summarize recent progress in cellular and functional identity of stem cells and distinctive niches in the lungs. We also describe the molecular mechanism of genetic and epigenetic program in the regulation of stem cell behavior during tissue regeneration. Lastly, we introduce the three-dimensional lung organoid platforms that provide valuable insights into the mechanisms of lung pathophysiology in human system.</div></div>","PeriodicalId":18795,"journal":{"name":"Molecules and Cells","volume":"48 8","pages":"Article 100241"},"PeriodicalIF":6.5000,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecules and Cells","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1016847825000652","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The respiratory system is an essential organ that performs gas exchange through the blood circulation in mammals. Unlike other organs, the lungs are directly exposed to the external environment, including particulate matter, cigarette smoke, and various pollutants, and are therefore, highly susceptible to damage. The lungs retain regional-specific stem/progenitor cells that quickly mobilize to replace the damaged epithelium. Accumulating evidences suggest that fate decision of stem cells relies on regulatory programs integrated by niches constituting the microenvironment providing diverse signals that regulate stem cell behavior. Therefore, understanding cellular diversity and precise interaction between stem cells and their respective niches is crucial to understand how tissue recovers homeostasis after injury. Here, in this review, we summarize recent progress in cellular and functional identity of stem cells and distinctive niches in the lungs. We also describe the molecular mechanism of genetic and epigenetic program in the regulation of stem cell behavior during tissue regeneration. Lastly, we introduce the three-dimensional lung organoid platforms that provide valuable insights into the mechanisms of lung pathophysiology in human system.

查看原文本刊更多论文

肺再生的构建模块：干细胞和壁龛。

呼吸系统是哺乳动物通过血液循环进行气体交换的重要器官。与其他器官不同，肺直接暴露于外部环境，包括颗粒物、香烟烟雾和各种污染物，因此极易受到损害。肺保留了区域特异性的干细胞/祖细胞，这些细胞可以迅速动员起来取代受损的上皮。越来越多的证据表明，干细胞的命运决定依赖于由构成微环境的生态位集成的调控程序，这些微环境提供各种信号来调节干细胞的行为。因此，了解细胞多样性以及干细胞与各自生态位之间的精确相互作用对于理解组织在损伤后如何恢复稳态至关重要。在这篇综述中，我们总结了近年来在肺中干细胞和独特生态位的细胞和功能鉴定方面的进展。我们还描述了在组织再生过程中调控干细胞行为的遗传和表观遗传程序的分子机制。最后，我们介绍了三维肺类器官平台，为了解人体系统肺病理生理机制提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecules and Cells 生物-生化与分子生物学

CiteScore

6.60

自引率

10.50%

发文量

审稿时长

2.3 months

期刊介绍： Molecules and Cells is an international on-line open-access journal devoted to the advancement and dissemination of fundamental knowledge in molecular and cellular biology. It was launched in 1990 and ISO abbreviation is "Mol. Cells". Reports on a broad range of topics of general interest to molecular and cell biologists are published. It is published on the last day of each month by the Korean Society for Molecular and Cellular Biology.