{"title":"Keep calm but do not carry on: ethical issues with the recommendations made by the Cass Review (2024).","authors":"Simona Giordano","doi":"10.1136/jme-2024-110613","DOIUrl":null,"url":null,"abstract":"<p><p>This paper discusses some of the ethical and legal issues that the recommendations contained in the Cass Review raise. It focuses, in particular, on the recommendation that hormonal treatment in the form of puberty blockers be made available only within a clinical trial. This paper explains why a clinical trial is highly unlikely to expand the evidence base in the way stated in the Review, and that other kinds of research, such as observational and longitudinal studies, are much more likely to be useful in this context. Those other kinds of research, however, are considered by Cass to provide low quality of evidence. In addition to the feasibility of clinical trials in this context, there are important ethical issues, which relate to consent and its voluntariness.</p>","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Ethics","FirstCategoryId":"98","ListUrlMain":"https://doi.org/10.1136/jme-2024-110613","RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ETHICS","Score":null,"Total":0}
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Abstract
This paper discusses some of the ethical and legal issues that the recommendations contained in the Cass Review raise. It focuses, in particular, on the recommendation that hormonal treatment in the form of puberty blockers be made available only within a clinical trial. This paper explains why a clinical trial is highly unlikely to expand the evidence base in the way stated in the Review, and that other kinds of research, such as observational and longitudinal studies, are much more likely to be useful in this context. Those other kinds of research, however, are considered by Cass to provide low quality of evidence. In addition to the feasibility of clinical trials in this context, there are important ethical issues, which relate to consent and its voluntariness.
期刊介绍：
Journal of Medical Ethics is a leading international journal that reflects the whole field of medical ethics. The journal seeks to promote ethical reflection and conduct in scientific research and medical practice. It features articles on various ethical aspects of health care relevant to health care professionals, members of clinical ethics committees, medical ethics professionals, researchers and bioscientists, policy makers and patients.
Subscribers to the Journal of Medical Ethics also receive Medical Humanities journal at no extra cost.
JME is the official journal of the Institute of Medical Ethics.
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