Do Skin Prick Tests Predict Nasal Provocation Test Outcomes in Allergic Rhinitis Patients?

IF 7.2 2区医学 Q1 OTORHINOLARYNGOLOGY

International Forum of Allergy & Rhinology Pub Date : 2025-06-16 DOI:10.1002/alr.23622

Yunhyung Lee, Gyu Tae Kim, Seo Jun Kang, Marn Joon Park

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引用次数: 0

Abstract

Background: In diagnosing allergic rhinitis (AR), conventional skin prick tests (SPTs) often fail to reflect allergen-induced nasal symptoms. Conversely, nasal provocation tests (NPTs) provide more definitive assessments but are less accessible. Therefore, we aimed to evaluate the correlation between SPT and NPT outcomes to assess SPT's predictive reliability for NPT results.

Methods: A retrospective review was performed on 106 patients who underwent simultaneous SPT and NPT for suspected perennial AR. The SPT was assessed by measuring the mean wheal diameter of Dermatophagoides pteronyssinus (Dp). The NPT was performed by administering 100 µL of a 1000 AU/mL Dp solution into both nostrils, with responses assessed by changes in the five AR-related symptoms (total nasal symptom score, TNSS) at 15 min. Correlation and linear regression analyses were conducted to evaluate the relationship between SPT and NPT outcomes.

Results: TNSS changes at 15 min following intranasal Dp challenge showed a significant, moderately positive correlation with SPT Dp wheal diameter for all 106 subjects (ρ = 0.640, p < 0.001). In patients positive for both SPT and NPT (n = 24, ρ = 0.510, p = 0.011) and those with monosensitization (n = 30, ρ = 0.644, p < 0.001), a stronger and significant correlation was observed compared to the polysensitized group (n = 35, ρ = 0.372, p = 0.028), while no significant correlation was noted in patients negative for either test. Linear regression confirmed a significant linear relationship (R² = 0.423, Y = 2.65X - 0.59, p < 0.001) between SPT wheal size and 15-min TNSS changes in NPT among all the subjects.

Conclusion: Significant correlations and linear associations between SPT and NPT outcomes support SPT's predictive capability for NPT responses.

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皮肤点刺试验能预测变应性鼻炎患者鼻激发试验的结果吗？

背景：在诊断变应性鼻炎（AR）时，传统的皮肤点刺试验（SPTs）往往不能反映过敏原引起的鼻症状。相反，鼻腔激发试验（NPTs）提供更明确的评估，但不易获得。因此，我们旨在评估SPT与NPT结果之间的相关性，以评估SPT对NPT结果的预测可靠性。方法：对106例疑似多年性AR同时行SPT和NPT的患者进行回顾性分析。SPT通过测量翼状窦皮囊平均轮径（Dp）来评估。将100µL 1000 AU/mL的Dp溶液注入双鼻孔进行非扩散试验，通过15分钟内5种ar相关症状（总鼻症状评分，TNSS）的变化来评估反应。进行相关性和线性回归分析，以评估SPT与非扩散试验结果之间的关系。结果：鼻内Dp攻击后15分钟的TNSS变化与所有106名受试者的SPT Dp轮直径呈显著的中度正相关（ρ = 0.640, p 2 = 0.423, Y = 2.65X - 0.59, p）结论：SPT和NPT结果之间的显著相关性和线性关联支持SPT对NPT反应的预测能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Forum of Allergy & Rhinology OTORHINOLARYNGOLOGY-

CiteScore

11.70

自引率

10.90%

发文量

185

审稿时长

6-12 weeks

期刊介绍： International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy. International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.