Venere Cortazzo, Marilena Agosta, Domenico Umberto De Rose, Valeria Fox, Velia Chiara Di Maio, Gianluca Vrenna, Martina Rossitto, Barbara Lucignano, Stefania Ranno, Annamaria Sisto, Cristina Russo, Annabella Braguglia, Maria Paola Ronchetti, Andrea Dotta, Carlo Federico Perno, Paola Bernaschi
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引用次数: 0
Abstract
Background: Acute bronchiolitis is a leading cause of hospitalization in young children worldwide, and literature reports conflicting data regarding the role of coinfections.
Objective: To evaluate the possible clinical relevance of bacterial and/or viral respiratory coinfection in a cohort of newborns/infants hospitalized for bronchiolitis.
Methods: Neonates and infants younger than three months admitted to neonatal units from October 2021 to March 2023 because of acute bronchiolitis were included in this retrospective study. Analyses were performed with Stata 11.1 (p < 0.05). Data were summarized as medians (IQR) or counts (%). Appropriate tests were used based on data type and distribution, with Benjamini-Hochberg correction for multiple comparisons. Odd Ratios (ORs) were unadjusted.
Results: In a cohort of 240 patients, respiratory coinfection was associated with a longer hospital stay (p < 0.001) and the need for invasive mechanical ventilation (p < 0.001) compared to viral mono-infection, highlighting a potential role in patient outcome. Moreover, we observed that premature patients are more likely to contract a respiratory coinfection than a viral mono-infection (p = 0.011).
Conclusion: Coinfections increased the clinical severity of bronchiolitis more than simple viral mono-infection in our cohort, contributing to a longer hospital stay and the need for invasive mechanical ventilation.
背景：急性细支气管炎是全世界幼儿住院的主要原因，文献报道了关于合并感染作用的相互矛盾的数据。目的：评估因毛细支气管炎住院的新生儿/婴儿中细菌和/或病毒呼吸道合并感染的可能临床意义。方法：本回顾性研究纳入了2021年10月至2023年3月因急性细支气管炎入住新生儿病房的新生儿和3个月以下的婴儿。使用Stata 11.1进行分析(p结果：在240例患者的队列中，呼吸道合并感染与较长的住院时间相关（p p p = 0.011）。结论：在我们的队列中，合并感染比单纯的单一病毒感染增加了毛细支气管炎的临床严重程度，导致住院时间更长，需要有创机械通气。
期刊介绍：
Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.
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