Case Report: Positive Mycoplasma pneumoniae IgM does not necessarily indicate acute infection: two case studies.

IF 2.1 3区医学 Q2 PEDIATRICS

Frontiers in Pediatrics Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI:10.3389/fped.2025.1520021

Hao Wang, Xiaoying Liu, Yabin Wu, Xin Cao, Jie Liu, Wei Li

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引用次数: 0

Abstract

Background: We aimed to explore the duration of IgM antibodies against Mycoplasma pneumoniae.

Methods: Data from two children who consistently tested positive for M. pneumoniae IgM antibodies were retrospectively analyzed. Moreover, we examined the etiological data and drug use of these cases. Serologic testing using the colloidal gold method, direct chemiluminescence technique, and specific immune agglutination test were utilized. Quantitative PCR was used to detect M. pneumoniae in bronchoalveolar lavage fluid and antigen tests and nucleic acid detection were conducted for other respiratory pathogens.

Results: The serological positivity of M. pneumoniae IgM antibody persisted for nearly ten months in one child and more than fifteen months in the other child. Furthermore, the persistently positive M. pneumoniae IgM antibody tests led to the inappropriate use of macrolides during multiple hospitalizations.

Conclusions: IgM antibodies against M. pneumoniae may remain positive for an extended duration. Therefore, a positive Mycoplasma pneumoniae IgM test does not necessarily indicate the presence of an acute infection.

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病例报告：肺炎支原体IgM阳性不一定表明急性感染：两个病例研究。

背景：我们旨在探讨抗肺炎支原体IgM抗体的持续时间。方法：回顾性分析两名肺炎支原体IgM抗体持续检测呈阳性的儿童的数据。此外，我们检查了这些病例的病因学资料和药物使用情况。采用胶体金法、直接化学发光技术和特异性免疫凝集试验进行血清学检测。采用定量PCR检测支气管肺泡灌洗液中的肺炎支原体，并对其他呼吸道病原菌进行抗原检测和核酸检测。结果：肺炎支原体IgM抗体血清学阳性1例持续近10个月，1例持续15个月以上。此外，肺炎支原体IgM抗体检测持续阳性导致多次住院期间不适当使用大环内酯类药物。结论：抗肺炎支原体IgM抗体可能在较长时间内保持阳性。因此，一个阳性的肺炎支原体IgM测试并不一定表明急性感染的存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health

CiteScore

3.60

自引率

7.70%

发文量

2132

审稿时长

14 weeks

期刊介绍： Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.