Current developments of metal- and metalloid-based quinoline compounds as leishmanicidal agents.

IF 3.8 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Frontiers in Chemistry Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI:10.3389/fchem.2025.1586044

Edgar Del Carpio, Lino Hernández, Vito Lubes, Francisco Jourdan, Hugo Cerecetto, Gonzalo Scalese, Dinorah Gambino, Angel H Romero

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Abstract

The quinoline moiety represents an important scaffold for the development of leishmanicidal agents. In particular, its hybridization with metal/metalloids has generated highly active compounds that are, in some cases, highly selective against leishmaniasis models. The existing leishmanicidal metal-/metalloid-quinoline compounds are mainly based on the following: (i) coordination compounds based on 8-hydroxyquinolinate; (ii) metallocene derivatives; (iii) N-heterocyclic carbene (NHC) complexes featuring a quinoline moiety. This mini-review summarizes the reported cases of leishmanicidal metal and metalloid-based quinoline compounds for each group (i-iii), focusing on the structure-property relationship from in vitro Leishmania models and mechanisms of action, in vivo experiments, and pharmacokinetic data, if available. This paper aims to describe the state of the art of inorganic medicinal chemistry for the development of selective and potent leishmanicidal agents using the quinoline moiety.

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金属及金属基喹啉类化合物作为利什曼尼杀灭剂的研究进展。

喹啉部分是开发利什曼尼毒剂的重要支架。特别是，它与金属/类金属的杂交产生了高活性化合物，在某些情况下，对利什曼病模型具有高度选择性。现有的利什曼尼类金属/金属喹啉类化合物主要基于以下几种类型：(1)8-羟基喹啉基配位化合物；茂金属衍生物；（iii）含有喹啉部分的n -杂环碳（NHC）配合物。这篇综述总结了每一类（i-iii）利什曼原虫金属和金属基喹啉化合物的报道病例，重点介绍了体外利什曼原虫模型和作用机制的结构-性质关系、体内实验和药代动力学数据（如果有的话）。本文旨在介绍利用喹啉部分开发选择性强效利什曼尼杀灭剂的无机药物化学的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Chemistry Chemistry-General Chemistry

CiteScore

8.50

自引率

3.60%

发文量

1540

审稿时长

12 weeks

期刊介绍： Frontiers in Chemistry is a high visiblity and quality journal, publishing rigorously peer-reviewed research across the chemical sciences. Field Chief Editor Steve Suib at the University of Connecticut is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to academics, industry leaders and the public worldwide. Chemistry is a branch of science that is linked to all other main fields of research. The omnipresence of Chemistry is apparent in our everyday lives from the electronic devices that we all use to communicate, to foods we eat, to our health and well-being, to the different forms of energy that we use. While there are many subtopics and specialties of Chemistry, the fundamental link in all these areas is how atoms, ions, and molecules come together and come apart in what some have come to call the “dance of life”. All specialty sections of Frontiers in Chemistry are open-access with the goal of publishing outstanding research publications, review articles, commentaries, and ideas about various aspects of Chemistry. The past forms of publication often have specific subdisciplines, most commonly of analytical, inorganic, organic and physical chemistries, but these days those lines and boxes are quite blurry and the silos of those disciplines appear to be eroding. Chemistry is important to both fundamental and applied areas of research and manufacturing, and indeed the outlines of academic versus industrial research are also often artificial. Collaborative research across all specialty areas of Chemistry is highly encouraged and supported as we move forward. These are exciting times and the field of Chemistry is an important and significant contributor to our collective knowledge.