NK cell activity in the tumor microenvironment.

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1609479

A V Kuznetsova, X A Glukhova, I P Beletsky, A A Ivanov

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Abstract

The formation of an immunosuppressive tumor microenvironment (TME) impairs natural killer (NK) cell infiltration and persistence within tumor tissue and significantly diminishes NK-mediated cytotoxicity. This presents a substantial barrier to the efficacy of NK cell therapy in solid tumors. Current strategies aim to overcome immune evasion by enhancing NK cell recognition and cytotoxicity, while promoting their persistence, infiltration, and resistance to the TME. This review focusses on the biophysical characteristics of TME and specific components of the extracellular matrix (ECM) that affect NK cell activity, with the goal of identifying therapeutic approaches to modulate the TME and create a supportive niche for adaptive immune cell function. Advancements in interdisciplinary collaborations integrating oncology, cell biology, physics, engineering, materials science, and nanotechnology are crucial in advancing therapeutic strategies targeting ECM rigidity and mechanotransduction signaling pathways.

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肿瘤微环境中NK细胞的活性。

免疫抑制肿瘤微环境（TME）的形成会损害自然杀伤细胞（NK）在肿瘤组织中的浸润和持久性，并显著降低NK介导的细胞毒性。这对NK细胞治疗实体瘤的疗效提出了实质性的障碍。目前的策略旨在通过增强NK细胞识别和细胞毒性来克服免疫逃避，同时促进其持久性，浸润性和对TME的抵抗力。这篇综述的重点是TME的生物物理特性和影响NK细胞活性的细胞外基质（ECM）的特定成分，目的是确定调节TME的治疗方法，并为适应性免疫细胞功能创造一个支持的生态位。整合肿瘤学、细胞生物学、物理学、工程学、材料科学和纳米技术的跨学科合作的进展对于推进针对ECM刚性和机械转导信号通路的治疗策略至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.