{"title":"Bilirubin may mediate the anti-inflammatory effects of aerobic exercise habits: implications for the antiatherosclerotic effects of aerobic exercise.","authors":"Shigemasa Tani, Yasuyuki Suzuki, Tsukasa Yagi, Atsuhiko Takahashi","doi":"10.1097/MCA.0000000000001546","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Moderately elevated serum bilirubin levels and aerobic exercise effectively reduce the risk of coronary artery disease (CAD). However, the relationships among aerobic exercise, total serum bilirubin (TSB), and inflammation remain unclear. We investigated the associations among aerobic exercise, TSB, and inflammatory response, with TSB as a mediator of this association.</p><p><strong>Methods: </strong>This cross-sectional study included 8290 participants registered at the Health Planning Center of Nihon University Hospital in 2019. We defined aerobic exercise as 30 min of sweating at least twice a week for over a year.</p><p><strong>Results: </strong>In this cohort (average age, 46.7±13.0 years; 59% men), participants who undertook habitual aerobic exercise (n=2131) had significantly higher TSB levels [0.78 (0.91/0.99) mg/dl vs. 0.74 (0.58/0.95) mg/dl, P<0.0001] than those who did not (n=6159). Multivariable logistic regression analysis demonstrated that aerobic exercise independently predicted higher TSB levels (>50th percentile set as the dependent variable). Participants with habitual aerobic exercise had significantly lower inflammatory blood cell components, including leukocyte, neutrophil, and platelet counts, than those who did not (all P<0.0001). The levels of these inflammatory markers significantly decreased with increasing TSB levels. Mediation analysis indicated that higher TSB levels partially mediated the association between aerobic exercise and lower counts of inflammatory markers.</p><p><strong>Conclusion: </strong>Habitual aerobic exercise was associated with lower levels of inflammatory markers and higher TSB levels, which mediated the anti-inflammatory effects of aerobic exercise. These associations potentially elucidate the preventive effects of aerobic exercise on CAD risk.</p>","PeriodicalId":10702,"journal":{"name":"Coronary artery disease","volume":" ","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coronary artery disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MCA.0000000000001546","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Moderately elevated serum bilirubin levels and aerobic exercise effectively reduce the risk of coronary artery disease (CAD). However, the relationships among aerobic exercise, total serum bilirubin (TSB), and inflammation remain unclear. We investigated the associations among aerobic exercise, TSB, and inflammatory response, with TSB as a mediator of this association.
Methods: This cross-sectional study included 8290 participants registered at the Health Planning Center of Nihon University Hospital in 2019. We defined aerobic exercise as 30 min of sweating at least twice a week for over a year.
Results: In this cohort (average age, 46.7±13.0 years; 59% men), participants who undertook habitual aerobic exercise (n=2131) had significantly higher TSB levels [0.78 (0.91/0.99) mg/dl vs. 0.74 (0.58/0.95) mg/dl, P<0.0001] than those who did not (n=6159). Multivariable logistic regression analysis demonstrated that aerobic exercise independently predicted higher TSB levels (>50th percentile set as the dependent variable). Participants with habitual aerobic exercise had significantly lower inflammatory blood cell components, including leukocyte, neutrophil, and platelet counts, than those who did not (all P<0.0001). The levels of these inflammatory markers significantly decreased with increasing TSB levels. Mediation analysis indicated that higher TSB levels partially mediated the association between aerobic exercise and lower counts of inflammatory markers.
Conclusion: Habitual aerobic exercise was associated with lower levels of inflammatory markers and higher TSB levels, which mediated the anti-inflammatory effects of aerobic exercise. These associations potentially elucidate the preventive effects of aerobic exercise on CAD risk.
期刊介绍：
Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management.
Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
