Preoperative tyrosine is associated with postoperative delayed neurocognitive recovery in elderly: Evidence from two hospitals

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-06-13 DOI:10.1016/j.clnesp.2025.06.016

Lei Zhang , Jianhui Liu , Ren Zhou , Jiehui Liu , Jingya Zhang , Haoli Mao , Jia Yan , Hong Jiang

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引用次数: 0

Abstract

Background

Elderly individuals have metabolite alterations that may contribute to delayed neurocognitive recovery (dNCR) following surgery and exposure to anesthesia. Despite its increasing popularity in geriatrics and aging research, dNCR currently lacks specific biomarkers, impeding diagnosis and potential clinical interventions.

Objectives

To determine which metabolites could serve as clinically valuable biomarkers for dNCR.

Methods

Preoperative serum metabolomics were measured in two cohorts: cohort 1 (TJ; N = 43) and cohort 2 (JY; N = 67). dNCR was measured with neuropsychological tests. Differential metabolites were selected from orthogonal partial least-squares discrimination analysis and validated by internal standards. We used logistic regression to examine associations and receiver operating characteristic curves to evaluate predictive ability.

Results

Preoperative serum tyrosine levels were significantly decreased in dNCR compared to non-dNCR groups. Tyrosine levels were associated with dNCR after adjusting for possible confounders in all participants and in subgroup analyses. Areas under the curve were 0.73 in all participants, 0.82 in the TJ cohort, and 0.67 in the JY cohort.

Conclusions

Low preoperative blood tyrosine levels were associated with increased risk of postoperative dNCR in elderly patients.

This trial was registered with chictr.org.cn (ChiCTR2200057080) and clinicaltrials.gov (NCT05105451).

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术前酪氨酸与老年人术后延迟神经认知恢复相关：来自两家医院的证据

背景：老年人的代谢物改变可能导致手术和麻醉后延迟神经认知恢复（dNCR）。尽管在老年病学和衰老研究中越来越受欢迎，但dNCR目前缺乏特异性的生物标志物，阻碍了诊断和潜在的临床干预。目的：确定哪些代谢物可以作为临床上有价值的dNCR生物标志物。方法：术前血清代谢组学测定分为两组：队列1 (TJ；N = 43)和队列2 (JY；N = 67)。dNCR采用神经心理测试测量。通过正交偏最小二乘判别分析选择差异代谢物，并用内标进行验证。我们使用逻辑回归来检验相关性和受试者工作特征曲线来评估预测能力。结果：与非dNCR组相比，dNCR组术前血清酪氨酸水平明显降低。在所有参与者和亚组分析中调整了可能的混杂因素后，酪氨酸水平与dNCR相关。所有受试者的曲线下面积为0.73，TJ组为0.82，JY组为0.67。结论：术前低血酪氨酸水平与老年患者术后dNCR风险增加相关。该试验已在chictr.org.cn （ChiCTR2200057080）和clinicaltrials.gov （NCT05105451）注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.