Maternal and neonatal vitamin D levels and hyperbilirubinemia: A systematic review and meta-analysis

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-06-13 DOI:10.1016/j.clnesp.2025.06.030

Arezoo Ghavi , Kathleen L. Meert , Mohammad Asghari-Jafarabadi , Rebecca Hill Renirie , Zahra Mohammadi-Pirouz

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引用次数: 0

Abstract

Background & aims

Vitamin D (Vit D) deficiency during pregnancy may have potential adverse effects on the health of mothers and neonates. The relationship between Vit D deficiency and neonatal hyperbilirubinemia is unknown. The aim of this study is to determine the relationship between Vit D levels in mothers and neonates and the occurrence of neonatal hyperbilirubinemia.

Methods

This systematic review and meta-analysis were guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A literature search was conducted in electronic databases: PubMed, Cochrane, CINAHL, Scopus, Web of Science, Ovid MEDLINE, and MEDLINE Ultimate until the end of 2024 to find studies published in English that investigated Vit D levels in mothers or neonates and their associations with hyperbilirubinemia. The Newcastle Ottawa Scale (NOS) tool was used to assess the quality of the articles included. A random effects model was used for (subgroup) meta-analyses, assessing heterogeneity with I-squared, publication bias with funnel plot, Egger and Begg tests, and conducting meta-regression to explore heterogeneity sources.

Results

Of the 29 studies included in this systematic review, 25 were eligible for meta-analysis. Despite the overall lack of significant results in some aspects of this meta-analysis, the random-effects model showed that Vit D levels were significantly lower during pregnancy in mothers of neonates with hyperbilirubinemia compared to mothers of neonates without hyperbilirubinemia (MD: −7.98 nmol/L, 95%CI: −11.02 to −4.94, I2: 49.82 %, p < 0.001). Additionally, Vit D levels were significantly lower in neonates with hyperbilirubinemia compared to neonates without hyperbilirubinemia (MD: −19.53 nmol/L, 95%CI: −25.42 to −13.64, I2: 93.76 %, p < 0.001).

Conclusions

This review suggests that higher maternal Vit D levels during pregnancy may lead to higher Vit D levels in neonates and ultimately a lower risk of neonatal hyperbilirubinemia.

查看原文本刊更多论文

产妇和新生儿维生素D水平与高胆红素血症：系统回顾和荟萃分析。

背景与目的：妊娠期维生素D （Vit D）缺乏可能对母亲和新生儿的健康产生潜在的不良影响。维生素D缺乏与新生儿高胆红素血症之间的关系尚不清楚。本研究的目的是确定母亲和新生儿维生素D水平与新生儿高胆红素血症发生之间的关系。方法：本系统评价和荟萃分析以系统评价和荟萃分析首选报告项目（PRISMA）为指导。在PubMed、Cochrane、CINAHL、Scopus、Web of Science、Ovid MEDLINE和MEDLINE Ultimate等电子数据库中进行文献检索，直到2024年底，寻找已发表的关于调查母亲或新生儿维生素D水平及其与高胆红素血症相关性的英文研究。使用纽卡斯尔渥太华量表（NOS）工具评估纳入文章的质量。采用随机效应模型进行（亚组）meta分析，采用i平方法评估异质性，采用漏斗图、Egger和Begg检验评估发表偏倚，并进行meta回归探讨异质性来源。结果：本系统综述纳入的29项研究中，有25项符合meta分析的条件。尽管该荟萃分析的某些方面总体上缺乏显著结果，但随机效应模型显示，与未患高胆红素血症的新生儿母亲相比，患有高胆红素血症的新生儿母亲妊娠期间的Vit D水平显著降低（MD: -7.98 nmol/L, 95%CI: -11.02至-4.94,I2: 49.82%, p < 0.001）。此外，与没有高胆红素血症的新生儿相比，高胆红素血症新生儿的Vit D水平显著降低（MD: -19.53 nmol/L, 95%CI: -25.42 ~ -13.64, I2: 93.76%, p < 0.001）。结论：本综述提示，妊娠期间较高的母体维生素D水平可能导致新生儿较高的维生素D水平，最终降低新生儿高胆红素血症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.