Health-Related Quality of Life Among People Living with HIV in Vietnam, a Three-Year Longitudinal Analysis

IF 2.4 2区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

AIDS and Behavior Pub Date : 2025-06-16 DOI:10.1007/s10461-025-04788-7

Hao T. Duong, Cuong D. Do, Donn J. Colby, Todd M. Pollack

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Abstract

This study examined changes in health-related quality of life (HRQOL) among people living with HIV in Vietnam over three years following antiretroviral therapy (ART) initiation. We analyzed data from a randomized trial of 639 ART-naïve patients in which HRQOL was measured using the SF-8 instrument. Mixed effects logistic regression was used to assess changes in HRQOL over time and identify associated factors. At baseline, 57.5% reported low HRQOL. HRQOL improved rapidly after ART initiation, with 89.0% reporting good HRQOL at 3 months and 96.4% at 36 months. Compared with men, women had slower improvement in HRQOL over time. Factors positively associated with HRQOL included higher BMI and alcohol use, while food insecurity, history of tuberculosis, advanced clinical stages, and TDF-based regimens were negatively associated. Older age was linked to poorer HRQOL outcomes. These findings highlight the effectiveness of ART in improving HRQOL while also revealing disparities in HRQOL improvements.

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越南艾滋病毒感染者与健康相关的生活质量：一项为期三年的纵向分析

这项研究调查了越南艾滋病毒感染者在开始抗逆转录病毒治疗（ART）后三年内与健康相关的生活质量（HRQOL）的变化。我们分析了639例ART-naïve患者的随机试验数据，其中使用SF-8仪器测量HRQOL。使用混合效应逻辑回归评估HRQOL随时间的变化并确定相关因素。在基线时，57.5%的患者报告HRQOL较低。开始抗逆转录病毒治疗后，HRQOL迅速改善，89.0%报告3个月时HRQOL良好，96.4%报告36个月时HRQOL良好。与男性相比，随着时间的推移，女性的HRQOL改善速度较慢。与HRQOL呈正相关的因素包括较高的BMI和饮酒，而食物不安全、结核病史、晚期临床阶段和基于tdf的方案呈负相关。年龄越大，HRQOL结果越差。这些发现突出了ART在改善HRQOL方面的有效性，同时也揭示了HRQOL改善方面的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS and Behavior Multiple-

CiteScore

6.60

自引率

13.60%

发文量

382

期刊介绍： AIDS and Behavior provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews. provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews.5 Year Impact Factor: 2.965 (2008) Section ''SOCIAL SCIENCES, BIOMEDICAL'': Rank 5 of 29 Section ''PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH'': Rank 9 of 76