{"title":"Point-of-Care Photoresistive and Colorimetric Sensor for Iron Detection in Environmental and Biological Samples with Spectroscopic Validation.","authors":"Shrikant Kashyap, Purushotam Shivshakti Mahan, Harendra Singh, Sibnath Kayal, Tapas K Mandal","doi":"10.1002/asia.202500375","DOIUrl":null,"url":null,"abstract":"<p><p>The development of an innovative, selective, and portable digital photoresistive sensor for sensing iron in the environment and biological samples is reported in this article. Colorimetric sensing of the analyte is investigated, akin to the spectrophotometric absorption principle. Iron in the sample is measured by the formation of orange-colored ferroin resulting from the 1,10-phenanthroline reaction. The reaction scheme is designed to be pH-specific, simple, quick, and effective in detecting trace amounts of iron in real sample matrices without employing any tedious route of synthesis and its characterization. A digital photoresistive prototype is fabricated using a light-emitting diode (LED) and a light-dependent resistor (LDR) to measure the concentration of iron much less than the recommended value by the World Health Organization (WHO). The limit of detection (LOD) is reported to be 0.017 mg L<sup>-1</sup>, the lowest to date for the class of point of care (POC) devices. The sensor was tested on 55 real-life samples and exhibited good accuracy with UV-vis and AAS measurements with an average absolute % error of 3.258%-14.34%. The present prototype promises to be a user-friendly, cost-effective solution to the pressing need of monitoring iron for the environment and healthcare sector.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00375"},"PeriodicalIF":3.5000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry - An Asian Journal","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1002/asia.202500375","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The development of an innovative, selective, and portable digital photoresistive sensor for sensing iron in the environment and biological samples is reported in this article. Colorimetric sensing of the analyte is investigated, akin to the spectrophotometric absorption principle. Iron in the sample is measured by the formation of orange-colored ferroin resulting from the 1,10-phenanthroline reaction. The reaction scheme is designed to be pH-specific, simple, quick, and effective in detecting trace amounts of iron in real sample matrices without employing any tedious route of synthesis and its characterization. A digital photoresistive prototype is fabricated using a light-emitting diode (LED) and a light-dependent resistor (LDR) to measure the concentration of iron much less than the recommended value by the World Health Organization (WHO). The limit of detection (LOD) is reported to be 0.017 mg L-1, the lowest to date for the class of point of care (POC) devices. The sensor was tested on 55 real-life samples and exhibited good accuracy with UV-vis and AAS measurements with an average absolute % error of 3.258%-14.34%. The present prototype promises to be a user-friendly, cost-effective solution to the pressing need of monitoring iron for the environment and healthcare sector.
期刊介绍:
Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics.
Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews.
A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal.
Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).