H13N8 and H16N3 AIV Isolated From Shorebirds Can Replicate in the Rectum of Mice

IF 6.8 3区医学 Q1 VIROLOGY

Journal of Medical Virology Pub Date : 2025-06-17 DOI:10.1002/jmv.70455

Jiaqi Lan, Lanlan Liu, Xiang Li, Ru Ding, Jiali Zhu, Fengyi Qu, Boyu Zhai, Jinyan Wu, Yajun Wang, Siyuan Yang, Hongliang Chai, Xiangwei Zeng

引用次数: 0

Abstract

To investigate the pathogenicity and cross-species transmission potential of H13 and H16-subtype of low pathogenic avian influenza viruses (LPAIVs), two strains of H13N8 and H16N3 isolated from shorebirds were used to infect mice. Clinical signs were observed, and viral loads and cytokine expression levels were measured. The results showed that both H13N8 and H16N3 AIV exhibited low pathogenicity in mice and could replicate efficiently in the rectum of mice without prior adaptation. Compared with the PBS group, six cytokines were expressed at low levels, further confirming the low pathogenicity of the H13N8 and H16N3 strains in mice. The results indicate that both strains have the potential for cross-species transmission to mammals.

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从滨鸟分离的H13N8和H16N3 AIV可在小鼠直肠中复制

为了研究低致病性禽流感病毒（LPAIVs） H13和h16亚型的致病性和跨种传播潜力，采用从滨鸟中分离的H13N8和H16N3两株感染小鼠。观察临床症状，检测病毒载量和细胞因子表达水平。结果表明，H13N8和H16N3 AIV在小鼠中均表现出较低的致病性，且无需预先适应即可在小鼠直肠中高效复制。与PBS组相比，6种细胞因子的表达水平较低，进一步证实了H13N8和H16N3菌株对小鼠的低致病性。结果表明，这两种菌株都具有跨物种传播到哺乳动物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Virology 医学-病毒学

CiteScore

23.20

自引率

2.40%

发文量

777

审稿时长

1 months

期刊介绍： The Journal of Medical Virology focuses on publishing original scientific papers on both basic and applied research related to viruses that affect humans. The journal publishes reports covering a wide range of topics, including the characterization, diagnosis, epidemiology, immunology, and pathogenesis of human virus infections. It also includes studies on virus morphology, genetics, replication, and interactions with host cells. The intended readership of the journal includes virologists, microbiologists, immunologists, infectious disease specialists, diagnostic laboratory technologists, epidemiologists, hematologists, and cell biologists. The Journal of Medical Virology is indexed and abstracted in various databases, including Abstracts in Anthropology (Sage), CABI, AgBiotech News & Information, National Agricultural Library, Biological Abstracts, Embase, Global Health, Web of Science, Veterinary Bulletin, and others.