Fat Mass and Obesity-Associated (FTO) Gene (rs9939609) Polymorphism and Metabolic Syndrome: A Study Among Two Rural Communities of Assam, Northeast India Having Different Ancestry

IF 1.6 4区医学 Q1 ANTHROPOLOGY

American Journal of Human Biology Pub Date : 2025-06-17 DOI:10.1002/ajhb.70083

Ananya Jyoti Gogoi, Chandana Sarmah, Prasanta Kumar Borah

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引用次数: 0

Abstract

Introduction

Metabolic syndrome (MS) is a group of related physio-biochemical factors that greatly increase the risk of cardiovascular diseases, stroke, and overall mortality. The physio-biochemical factors associated with MS have been previously found to have a genetic basis. Recently, the Fat Mass and Obesity-Associated (FTO) gene has been found to have a significant role in obesity.

Objective

To determine the association of FTO gene rs9939609 polymorphism with MS in two rural communities of Assam, Northeast India, having different ancestry.

Methods

A cross-sectional study was conducted among unrelated adult male and female individuals of the Mising and Ahom communities of Dhemaji district, Assam. Genotyping for the FTO gene's rs9939609 polymorphism was performed on a subset of participants. Individuals with MS were cases, while controls were randomly chosen from those without MS. Participants were categorized into AA and TA/TT groups. The chi-square test was utilized to assess whether there is any significant difference in the distributions of various categorical variables across the FTO rs9939609 gene variants (AA and TT/TA). Logistic regression was conducted to assess the relationship between the FTO rs9939609 SNP and the risk of MS. All statistical analyses were performed using IBM SPSS Statistics 26.

Results

Individuals with the AA genotype were found to have significantly higher odds of developing MS than those with TA or TT genotypes, after adjusting for all sociodemographic, behavioral, physiological, biochemical, anthropometric, and body composition measures.

Conclusion

The present study indicated that variations within the FTO locus (specifically rs9939609) were associated with MS and its components among the Mising and Ahom communities.

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脂肪量与肥胖相关（FTO）基因（rs9939609）多态性与代谢综合征：印度东北部阿萨姆邦两个不同祖先农村社区的研究

代谢综合征（MS）是一组相关的生理生化因素，可大大增加心血管疾病、中风和总死亡率的风险。与多发性硬化症相关的生理生化因素已被发现具有遗传基础。最近，脂肪量与肥胖相关（FTO）基因被发现在肥胖中起着重要作用。目的探讨印度东北部阿萨姆邦两个不同祖先农村社区FTO基因rs9939609多态性与多发性硬化症的关系。方法对阿萨姆邦德马吉地区Mising和Ahom社区的无亲属成年男性和女性进行横断面研究。对一部分参与者进行FTO基因rs9939609多态性的基因分型。MS患者为病例，对照组为非MS患者，随机分为AA组和TA/TT组。采用卡方检验评估FTO rs9939609基因变异（AA和TT/TA）中各分类变量的分布是否存在显著差异。采用Logistic回归评估FTO rs9939609 SNP与ms风险之间的关系，所有统计分析均使用IBM SPSS Statistics 26进行。结果在调整了所有社会人口学、行为、生理、生化、人体测量和身体成分测量后，AA基因型个体发生MS的几率明显高于TA或TT基因型个体。结论在Mising和ahomm群体中，FTO位点（特别是rs9939609）的变异与MS及其组分相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Human Biology 生物-生物学

CiteScore

4.80

自引率

13.80%

发文量

124

审稿时长

4-8 weeks

期刊介绍： The American Journal of Human Biology is the Official Journal of the Human Biology Association. The American Journal of Human Biology is a bimonthly, peer-reviewed, internationally circulated journal that publishes reports of original research, theoretical articles and timely reviews, and brief communications in the interdisciplinary field of human biology. As the official journal of the Human Biology Association, the Journal also publishes abstracts of research presented at its annual scientific meeting and book reviews relevant to the field. The Journal seeks scholarly manuscripts that address all aspects of human biology, health, and disease, particularly those that stress comparative, developmental, ecological, or evolutionary perspectives. The transdisciplinary areas covered in the Journal include, but are not limited to, epidemiology, genetic variation, population biology and demography, physiology, anatomy, nutrition, growth and aging, physical performance, physical activity and fitness, ecology, and evolution, along with their interactions. The Journal publishes basic, applied, and methodologically oriented research from all areas, including measurement, analytical techniques and strategies, and computer applications in human biology. Like many other biologically oriented disciplines, the field of human biology has undergone considerable growth and diversification in recent years, and the expansion of the aims and scope of the Journal is a reflection of this growth and membership diversification. The Journal is committed to prompt review, and priority publication is given to manuscripts with novel or timely findings, and to manuscripts of unusual interest.