An analytical approach to modeling conjunctival viral disease using fuzzy logic and time-delay dynamics

Muhammad Tashfeen , Hothefa Shaker Jassim , Fazal Dayan , Muhammad Azizur Rehman , Alwahab Dhulfiqar Zoltán , Husam A. Neamah
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Abstract

Conjunctivitis, commonly known as pink eye, is the inflammation of the conjunctiva, often accompanied by redness, itchiness, and the discharge of thick white or greyish pus. Highly contagious in settings involving close contact, it poses significant public health and economic concerns. This study proposes a fuzzy mathematical modeling framework to investigate Conjunctival Viral Disease (CVD) transmission dynamics, with particular attention to the roles of asymptomatic carriers and environmental influences. Unlike conventional models that rely solely on deterministic parameters, the incorporation of fuzzy theory allows for representing uncertainties and variabilities inherent in real-world disease transmission. The model further incorporates time-delay terms to account for incubation periods and other latent effects, enhancing the accuracy of system dynamics. This fuzzy framework performs key analyses, including identifying equilibrium points, computation of the basic reproduction number, sensitivity analysis, and assessment of local and global stability. Numerical solutions are obtained using the Forward Euler and Nonstandard Finite Difference (NSFD) methods. The NSFD scheme is rigorously examined for convergence, non-negativity, boundedness, and consistency properties. Simulation results confirm that the NSFD approach maintains the qualitative features of the model even under larger time steps. Overall, the study underscores the importance of integrating fuzzy logic and time delays in epidemic modeling and presents a robust methodological approach for understanding and managing the spread of infectious diseases in uncertain and dynamic environments.
基于模糊逻辑和时滞动力学的结膜病毒病建模分析方法
结膜炎,俗称红眼病,是结膜的炎症,常伴有红肿、发痒,并排出浓稠的白色或灰色脓液。该病在密切接触的环境中具有高度传染性,造成重大的公共卫生和经济问题。本研究提出了一个模糊数学模型框架来研究结膜病毒病(CVD)的传播动力学,特别关注无症状携带者和环境影响的作用。与仅依赖确定性参数的传统模型不同,模糊理论的结合允许表示现实世界疾病传播中固有的不确定性和可变性。该模型进一步纳入了时滞项,以考虑潜伏期和其他潜在影响,提高了系统动力学的准确性。该模糊框架执行关键分析,包括确定平衡点,计算基本再现数,敏感性分析以及局部和全局稳定性评估。采用正演欧拉和非标准有限差分(NSFD)方法得到了数值解。对NSFD方案的收敛性、非负性、有界性和一致性进行了严格的检验。仿真结果表明,即使在较大的时间步长下,NSFD方法仍能保持模型的定性特征。总体而言,该研究强调了在流行病建模中集成模糊逻辑和时间延迟的重要性,并为在不确定和动态环境中理解和管理传染病的传播提供了强有力的方法方法。
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来源期刊
Healthcare analytics (New York, N.Y.)
Healthcare analytics (New York, N.Y.) Applied Mathematics, Modelling and Simulation, Nursing and Health Professions (General)
CiteScore
4.40
自引率
0.00%
发文量
0
审稿时长
79 days
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