Aligned poly(p-dioxanone) electrospun fibers modulate cellular response for dura mater regeneration

IF 4.9 2区化学 Q2 CHEMISTRY, PHYSICAL

Colloids and Surfaces A: Physicochemical and Engineering Aspects Pub Date : 2025-06-16 DOI:10.1016/j.colsurfa.2025.137507

Junqin Mao , Yutong Zhang , Qiuyu Zeng , Heng Zheng , Guoyu Lv

{"title":"Aligned poly(p-dioxanone) electrospun fibers modulate cellular response for dura mater regeneration","authors":"Junqin Mao , Yutong Zhang , Qiuyu Zeng , Heng Zheng , Guoyu Lv","doi":"10.1016/j.colsurfa.2025.137507","DOIUrl":null,"url":null,"abstract":"<div><div>Dural reconstruction, essential for protecting the central nervous system, remains challenging in cranial neurosurgery. This study discovers that the alignment of poly(p-dioxanone) (PPDO) electrospun fibers influences cellular behavior, thereby promoting dura mater regeneration without inducing excessive fibrosis. Electrospinning parameters were precisely optimized to fabricate PPDO fiber membranes exhibiting either isotropic or highly aligned morphologies. Quantitative analysis confirmed a clear relationship between electrospinning conditions and fiber alignment. The membranes displayed stable degradation characteristics suitable for biomedical applications. Notably, highly aligned PPDO membranes promoted spindle-shaped cellular morphology and enhanced secretion of three growth factors- alpha-smooth muscle actin (α-SMA), basic fibroblast growth factor (bFGF), and transforming growth factor-beta 1 (TGF-β1), facilitating favorable cellular responses for regeneration. These results display the significance of fiber orientation in designing advanced biomaterials for dura mater repair.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"724 ","pages":"Article 137507"},"PeriodicalIF":4.9000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0927775725014104","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Dural reconstruction, essential for protecting the central nervous system, remains challenging in cranial neurosurgery. This study discovers that the alignment of poly(p-dioxanone) (PPDO) electrospun fibers influences cellular behavior, thereby promoting dura mater regeneration without inducing excessive fibrosis. Electrospinning parameters were precisely optimized to fabricate PPDO fiber membranes exhibiting either isotropic or highly aligned morphologies. Quantitative analysis confirmed a clear relationship between electrospinning conditions and fiber alignment. The membranes displayed stable degradation characteristics suitable for biomedical applications. Notably, highly aligned PPDO membranes promoted spindle-shaped cellular morphology and enhanced secretion of three growth factors- alpha-smooth muscle actin (α-SMA), basic fibroblast growth factor (bFGF), and transforming growth factor-beta 1 (TGF-β1), facilitating favorable cellular responses for regeneration. These results display the significance of fiber orientation in designing advanced biomaterials for dura mater repair.

查看原文本刊更多论文

排列的聚对二氧环酮电纺丝纤维调节硬脑膜再生的细胞反应

硬脑膜重建对保护中枢神经系统至关重要，在颅神经外科中仍然具有挑战性。本研究发现聚（对二氧环酮）（PPDO）电纺丝纤维的排列影响细胞行为，从而促进硬脑膜再生而不诱导过度纤维化。对静电纺丝参数进行了精确优化，以制备具有各向同性或高度排列形态的PPDO纤维膜。定量分析证实了静电纺丝条件与纤维排列之间的明确关系。该膜具有稳定的降解特性，适合生物医学应用。值得注意的是，高度排列的PPDO膜促进了梭形细胞形态，并促进了三种生长因子- α-平滑肌肌动蛋白（α-SMA）、碱性成纤维细胞生长因子（bFGF）和转化生长因子-β1 （TGF-β1）的分泌，促进了有利的细胞再生反应。这些结果显示了纤维定向在设计先进的硬脑膜修复生物材料中的重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Colloids and Surfaces A: Physicochemical and Engineering Aspects 化学-物理化学

CiteScore

8.70

自引率

9.60%

发文量

2421

审稿时长

56 days

期刊介绍： Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena. The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.