Impact of air pollution and occupational inhalation exposures on neurodegenerative disorders: An epigenetic perspective

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-06-04 DOI:10.1016/j.isci.2025.112825

Paola Monti , Elia Biganzoli , Valentina Bollati

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Abstract

Neurodegenerative disorders (NDs) are highly prevalent conditions with genetic and environmental causes. Recently, air pollution has emerged as an important contributor to NDs, causing oxidative stress and neuronal damage in the brain. Identifying early molecular alterations mediating the effects of air pollution on ND pathogenesis would be crucial for implementing personalized medicine approaches, especially for the monitoring of specific categories of highly exposed workers. Epigenetic modifications might be suitable candidates in that sense, since they are highly responsive to environmental stressors, they modulate the expression of multiple ND-related genes, and offer technical advantages as they can be studies in peripheral tissues and are relatively stable in biological samples after collection.

In this review, we summarize the current knowledge regarding the association between air pollution inhalation, epigenetics, and NDs. This work will particularly emphasize research gaps, aiming to provide directions for future research with applications in occupational and preventive medicine.

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空气污染和职业性吸入暴露对神经退行性疾病的影响：一个表观遗传学的观点

神经退行性疾病（NDs）是由遗传和环境原因引起的非常普遍的疾病。最近，空气污染已成为NDs的一个重要因素，引起大脑氧化应激和神经元损伤。识别空气污染对ND发病机制影响的早期分子改变对于实施个性化医疗方法至关重要，特别是对于监测特定类别的高暴露工人。从这个意义上说，表观遗传修饰可能是合适的候选者，因为它们对环境应激源高度敏感，它们调节多种nd相关基因的表达，并且具有技术优势，因为它们可以在外周组织中进行研究，并且在收集后的生物样品中相对稳定。在这篇综述中，我们总结了目前关于空气污染吸入、表观遗传学和NDs之间关系的知识。本工作将特别强调研究空白，旨在为未来在职业和预防医学中的应用研究提供方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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