Platelet and immune cell crosstalk in dementia with Lewy bodies: Is there a unique inflammatory profile?

IF 2.5 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2025-06-13 DOI:10.1016/j.jneuroim.2025.578668

Noelia Arias , Marc Boigues , Lourdes Ispierto , Dolores Vilas , Ian Linares-Pardo , Ramiro Álvarez , Pau Pastor , Marco A. Fernandez-Sanmartín , Eva Martínez-Cáceres , Katrin Beyer

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引用次数: 0

Abstract

Neurodegenerative diseases such as dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and Parkinson's disease (PD) share overlapping clinical features, making diagnosis challenging. This study evaluated hematological data from blood tests of DLB, AD and PD patients and control individuals, 16 each. The interaction between platelets and immune cells was analyzed using flow cytometry to identify disease-specific differences. DLB patients exhibited a non-significant trend toward lower absolute platelet counts and reduced percentages of total monocytes especially compared to AD. Monocyte–platelet interactions were associated with a significant increase of CD68 expression, which was more pronounced in DLB than in AD and PD. The CD68 receptor, a marker of monocyte and microglial activation and receptor for low-density lipoproteins (LDL), was significantly increased in DLB compared to both AD and PD. Based on CD68 expression, platelet count and CD14⁺ monocyte percentage, we developed two multiparametric logistic models to classify DLB patients from AD (AUC: 0.8095) and PD (AUC: 0.8056). After further validation, these differences may help distinguish DLB from AD and PD.

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路易体痴呆的血小板和免疫细胞串扰：是否有独特的炎症特征？

神经退行性疾病，如路易体痴呆（DLB）、阿尔茨海默病（AD）和帕金森病（PD）具有重叠的临床特征，使诊断具有挑战性。本研究评估了DLB、AD和PD患者及对照个体（各16例）血液测试的血液学数据。利用流式细胞术分析血小板和免疫细胞之间的相互作用，以确定疾病特异性差异。与AD相比，DLB患者在绝对血小板计数和总单核细胞百分比降低方面表现出不显著的趋势。单核细胞-血小板相互作用与CD68表达显著增加相关，在DLB中比在AD和PD中更为明显。CD68受体是单核细胞和小胶质细胞激活的标志，也是低密度脂蛋白（LDL）的受体，与AD和PD相比，DLB患者的CD68受体显著升高。基于CD68表达、血小板计数和CD14+单核细胞百分比，我们建立了两个多参数logistic模型，将DLB患者分为AD （AUC: 0.8095）和PD （AUC: 0.8056）。经过进一步验证，这些差异可能有助于区分DLB与AD和PD。

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.