{"title":"Pivotal role of PPARγ in UTO","authors":"Louise Lloyd","doi":"10.1038/s41585-025-01061-3","DOIUrl":null,"url":null,"abstract":"<p>Activation of peroxisome proliferator-activated receptor-γ (PPARγ) in uroplakin-expressing cells in renal urothelium drives urothelial modelling induced by urinary tract obstruction (UTO), suggest preclinical data in <i>Experimental & Molecular Medicine</i>. These observations provide a potential therapeutic target for future UTO treatment.</p><p>In vivo, lineage analysis during unilateral ureteral obstruction (UUO) demonstrated that uroplakin expression is downregulated, proliferation increased and uroplakin reacquired in uroplakin-lineage cells. Between baseline and advanced stages of UUO, 168 differentially expressed genes were identified in uroplakin-expressing cells. PPARγ was among the top-ranked most affected transcription factors and its expression increased and it was activated in uroplakin-expressing cells during UUO.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"25 1","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41585-025-01061-3","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Activation of peroxisome proliferator-activated receptor-γ (PPARγ) in uroplakin-expressing cells in renal urothelium drives urothelial modelling induced by urinary tract obstruction (UTO), suggest preclinical data in Experimental & Molecular Medicine. These observations provide a potential therapeutic target for future UTO treatment.
In vivo, lineage analysis during unilateral ureteral obstruction (UUO) demonstrated that uroplakin expression is downregulated, proliferation increased and uroplakin reacquired in uroplakin-lineage cells. Between baseline and advanced stages of UUO, 168 differentially expressed genes were identified in uroplakin-expressing cells. PPARγ was among the top-ranked most affected transcription factors and its expression increased and it was activated in uroplakin-expressing cells during UUO.
期刊介绍：
Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline.
The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals.
Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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