Infants of hepatitis B surface antigen-positive women of Black ethnicity in the UK may be at risk of acquiring human T-cell lymphotropic virus type 1

IF 11.9 1区医学 Q1 INFECTIOUS DISEASES

Journal of Infection Pub Date : 2025-06-12 DOI:10.1016/j.jinf.2025.106533

Daniel Bradshaw , Panida Silalang , Nick Andrews , John Poh , Arham Khawar , Gary Murphy , Ruth Simmons , Monica Desai , Sema Mandal , Samreen Ijaz

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引用次数: 0

Abstract

Objectives

The UK’s antenatal screening and neonatal immunisation programme prevents vertical HBV transmissions. However, it is unknown whether HTLV-1 transmissions are occurring. We determined HTLV seroprevalence among hepatitis B surface antigen-positive individuals identified through antenatal enhanced surveillance between 27/03/2021 to 30/03/2023.

Results

For 3583 individuals, eight were HTLV-1 positive (2.2 per 1000, 95% CI 1.0 per 1000 to 4.4 per 1000) and none were HTLV-2 positive (95% CI 0.0 to 1.0 per 1000). HTLV-1 seroprevalence in women of Black ethnicity was 5.3 per 1000 (95%CI 2.1 per 1000 to 10.8 per 1000). Assuming 20% vertical transmission rates, over five years of the surveillance, it is likely that four (95% CI 1.0 – 10.0) infants avoidably acquired HTLV-1. As transmission can be prevented through education of HTLV-1 positive individuals to avoid breastfeeding, this represents a missed opportunity for averting neonatal infection.

Conclusions

Avoidable HTLV-1 vertical transmissions are likely occurring in this population, calling for strengthened public health interventions.

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在英国，乙型肝炎表面抗原阳性的黑人妇女的婴儿可能有感染1型人类t细胞嗜淋巴病毒的危险。

目的：英国的产前筛查和新生儿免疫规划防止垂直HBV传播。然而，目前尚不清楚HTLV-1是否正在传播。我们测定了2021年3月27日至2023年3月30日通过产前强化监测发现的乙型肝炎表面抗原阳性个体的HTLV血清阳性率。结果：在3583例个体中，8例HTLV-1阳性（2.2 / 1000,95% CI 1.0 / 1000 ~ 4.4 / 1000），无HTLV-2阳性（95% CI 0.0 ~ 1.0 / 1000）。黑人妇女HTLV-1血清患病率为5.3 / 1000（95%可信区间为2.1 / 1000至10.8 / 1000）。假设垂直传播率为20%，在5年的监测中，可能有4名（95% CI 1.0 - 10.0）婴儿可避免感染HTLV-1。由于可以通过教育HTLV-1阳性个体避免母乳喂养来预防传播，这意味着错过了避免新生儿感染的机会。结论：本可避免的HTLV-1垂直传播可能发生在这一人群中，呼吁加强公共卫生干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection 医学-传染病学

CiteScore

45.90

自引率

3.20%

发文量

475

审稿时长

16 days

期刊介绍： The Journal of Infection publishes original papers on all aspects of infection - clinical, microbiological and epidemiological. The Journal seeks to bring together knowledge from all specialties involved in infection research and clinical practice, and present the best work in the ever-changing field of infection. Each issue brings you Editorials that describe current or controversial topics of interest, high quality Reviews to keep you in touch with the latest developments in specific fields of interest, an Epidemiology section reporting studies in the hospital and the general community, and a lively correspondence section.