Point of view: Genomic landscape and molecularly informed therapy in thymic carcinoma and other advanced thymic epithelial tumors.

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2025-06-13 DOI:10.1016/j.medj.2025.100625

Fabio Conforti, Tommaso De Pas

引用次数: 0

Abstract

In this issue of Med,¹ Möhrmann et al. present a comprehensive analysis of 81 advanced thymic epithelial tumors (TETs). The study offers insights into the tumor mutational landscape, germline alterations, and the identification of different immunological subsets. An interesting finding is the identification of "hot" and "cold" subsets of thymic carcinoma (TC), the hot subset showing better outcome with immune checkpoint inhibitor (ICI) treatment.

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观点：胸腺癌和其他晚期胸腺上皮肿瘤的基因组景观和分子知情治疗。

在这一期的Med上，1 Möhrmann等人对81例晚期胸腺上皮肿瘤（TETs）进行了综合分析。该研究为肿瘤突变景观、种系改变和不同免疫亚群的鉴定提供了见解。一个有趣的发现是胸腺癌（TC）的“热”亚群和“冷”亚群的鉴定，热亚群在免疫检查点抑制剂（ICI）治疗下表现出更好的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.