Evolving role for eosinophils in cancer: from bench to bedside.

IF 17.5 1区 医学 Q1 ONCOLOGY
S Grisaru-Tal, E A Jacobsen, A Munitz
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引用次数: 0

Abstract

Eosinophils are increasingly recognized as important immune cells in the tumor microenvironment (TME). Recent technological advancements reveal their heterogeneity and complex context-dependent activities including the ability to elicit pro- or anti-tumorigenic effects. For instance, they can mediate cytotoxicity via highly eosinophil-specific granule proteins and reactive oxygen species, and contribute to antitumor immunity by interacting with various cells including T cells. Clinically, eosinophilia is often observed following various treatments including immunotherapy, where they may be beneficial for therapy. This Review explores eosinophil recruitment, immune interactions, therapeutic potential and methods for studying their activity. Understanding the role of eosinophils in the TME may lead to new therapeutic strategies and position them as targets or biomarkers in precision oncology.

嗜酸性粒细胞在癌症中的进化作用:从实验到临床。
嗜酸性粒细胞越来越被认为是肿瘤微环境(TME)中重要的免疫细胞。最近的技术进步揭示了它们的异质性和复杂的环境依赖活动,包括引发促或抗肿瘤作用的能力。例如,它们可以通过高度嗜酸性粒细胞特异性颗粒蛋白和活性氧介导细胞毒性,并通过与包括T细胞在内的各种细胞相互作用来促进抗肿瘤免疫。在临床上,嗜酸性粒细胞增多症经常在各种治疗后被观察到,包括免疫治疗,在那里它们可能对治疗有益。本文综述了嗜酸性粒细胞的募集、免疫相互作用、治疗潜力和研究其活性的方法。了解嗜酸性粒细胞在TME中的作用可能会导致新的治疗策略,并将其定位为精确肿瘤学的靶点或生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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