Pre-clinical evaluation of a divalent liposomal vaccine to control invasive candidiasis.

IF 6.9 1区 医学 Q1 IMMUNOLOGY
Augusto Costa-Barbosa, Maria Inês Pacheco, Andreia C Gomes, Tony Collins, Manuel Vilanova, Célia Pais, Alexandra Correia, Paula Sampaio
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引用次数: 0

Abstract

Candida albicans causes systemic infections with 20-50% mortality in critically ill and immunocompromised patients, despite antifungal treatment. Current therapies face limitations, including toxicity and resistance, underscoring the need for prophylactic vaccines. This study presents a novel divalent liposomal vaccine, delivering C. albicans Cht3 and Sap2 antigens. Vaccination induced protective Th1/Th17 immunity, a balanced Th1/Th2 ratio, antigen-specific antibodies, and boosted macrophage activity, improving survival in a mouse model of invasive candidiasis.

控制侵袭性念珠菌病的二价脂质体疫苗的临床前评价。
尽管进行了抗真菌治疗,但在危重病人和免疫功能低下的病人中,白色念珠菌引起全身感染,死亡率为20-50%。目前的治疗方法面临局限性,包括毒性和耐药性,强调需要预防性疫苗。本研究提出了一种新的二价脂质体疫苗,可递送白色念珠菌Cht3和Sap2抗原。在侵袭性念珠菌病小鼠模型中,接种疫苗可诱导保护性Th1/Th17免疫、平衡Th1/Th2比例、抗原特异性抗体,并提高巨噬细胞活性,提高生存率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
NPJ Vaccines
NPJ Vaccines Immunology and Microbiology-Immunology
CiteScore
11.90
自引率
4.30%
发文量
146
审稿时长
11 weeks
期刊介绍: Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.
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