The potential role of PAX5 and PAX8 in regulating telomerase activity: a narrative mini-review.

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biology Reports Pub Date : 2025-06-14 DOI:10.1007/s11033-025-10704-y

Amin Abdurrahman Abdul Rashid, Marahaini Musa, Siti Norasikin Mohd Nafi, Nazia Abdul Majid, Sarina Sulong

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引用次数: 0

Abstract

The ability to express replicative immortality is one of the hallmarks of cancer. Most of these cells attain this feature by expressing the enzyme telomerase. This enzyme is responsible for maintaining the telomeres, a repeating structure at the ends of chromosomes, protecting the chromosomes from degradation. The Paired Box (PAX) genes are a family of highly conserved genes involved in various functions, including the development of diseases like cancer, in which most of them express telomerase as the mechanism to maintain telomere length. This study seeks to investigate PAX genes as potential telomerase activators and explore emerging research areas. Related literature was retrieved from PubMed, Web of Science and Scopus databases using a keyword search, where 119 records were identified. However, upon further filtering, only four reports were relevant to this topic, which addresses the role of PAX5 and PAX8 genes and their proteins' role in telomerase regulation. More studies are needed to elucidate the complex mechanism of action between the PAX genes and telomerase regulation.

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PAX5和PAX8在调节端粒酶活性中的潜在作用：一个叙述性的小回顾。

表达复制永生的能力是癌症的标志之一。这些细胞大多通过表达端粒酶来获得这种特征。这种酶负责维持染色体末端的重复结构端粒，保护染色体免受降解。配对盒（Paired Box， PAX）基因是一个高度保守的基因家族，涉及多种功能，包括癌症等疾病的发生，其中大多数基因表达端粒酶作为维持端粒长度的机制。本研究旨在探讨PAX基因作为潜在的端粒酶激活剂，并探索新兴的研究领域。使用关键词检索从PubMed、Web of Science和Scopus数据库中检索相关文献，共检索到119条记录。然而，经过进一步筛选，只有四篇报道与本主题相关，这些报道涉及PAX5和PAX8基因及其蛋白在端粒酶调控中的作用。PAX基因与端粒酶调控之间的复杂作用机制有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biology Reports 生物-生化与分子生物学

CiteScore

5.00

自引率

0.00%

发文量

1048

审稿时长

5.6 months

期刊介绍： Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews.