Lipid droplet accumulation in microglia and their potential roles.

IF 3.9 2区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yunxia Li, Qi Zhao, Yan Wang, Wenyi Du, Riyun Yang, Jian Wu, Yi Li
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引用次数: 0

Abstract

Microglia are the resident immune cells of the central nervous system (CNS), where lipid metabolism is critical for maintaining homeostasis. In response to various external stimuli, they demonstrate a range of phenotypic expressions and lipid metabolic reprogramming. Lipid droplets (LDs) are dynamic organelles that function beyond energy storage, actively participating in neuropathological progress. Recent investigations have identified a subset of microglia characterized by the accumulation of LDs, referred to as "lipid-droplet-accumulating microglia" (LDAM). This review aims to investigate the processes involved in LD formation and degradation, the factors that modulate them, focusing particularly on the function of LDAM and their implications for CNS disorders. By synthesizing current evidence, we clarify the biological significance of LDs in these cells and their therapeutic targeting potential, providing new directions for future research.

Abstract Image

Abstract Image

Abstract Image

小胶质细胞脂滴积聚及其潜在作用。
小胶质细胞是中枢神经系统(CNS)的常驻免疫细胞,其中脂质代谢对维持体内平衡至关重要。在对各种外部刺激的反应中,它们表现出一系列表型表达和脂质代谢重编程。脂滴(LDs)是一种动态细胞器,具有能量储存以外的功能,积极参与神经病理进程。最近的研究发现了一种以脂滴积聚为特征的小胶质细胞亚群,称为“脂滴积聚小胶质细胞”(LDAM)。这篇综述旨在探讨LD形成和降解的过程,以及调节它们的因素,特别关注LDAM的功能及其对中枢神经系统疾病的影响。通过综合现有证据,我们阐明了lld在这些细胞中的生物学意义及其治疗靶向潜力,为未来的研究提供了新的方向。
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来源期刊
Lipids in Health and Disease
Lipids in Health and Disease 生物-生化与分子生物学
CiteScore
7.70
自引率
2.20%
发文量
122
审稿时长
3-8 weeks
期刊介绍: Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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